An unexplored diversity of reverse transcriptases in bacteria

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dc.contributor.authorZimmerly, Steven
dc.contributor.authorWu, Li
dc.date.accessioned2016-04-15T22:40:36Z
dc.date.available2016-04-15T22:40:36Z
dc.date.issued2015
dc.description.abstractReverse transcriptases (RTs) are usually thought of as eukaryotic enzymes, but they are also present in bacteria and likely originated in bacteria and migrated to eukaryotes. Only three types of bacterial retroelements have been substantially characterized: group II introns, diversity-generating retroelements, and retrons. Recent work, however, has identified a myriad of uncharacterized RTs and RT-related sequences in bacterial genomes, which exhibit great sequence diversity and a range of domain structures. Apart from group II introns, none of these putative RTs show evidence of active retromobility. Instead, available information suggests that they are involved in useful processes, sometimes related to phages or phage resistance. This article reviews our knowledge of both characterized and uncharacterized RTs in bacteria. The range of their sequences and genomic contexts promises the discovery of new biochemical reactions and biological phenomena.en_US
dc.description.refereedYesen_US
dc.identifier.citationZimmerly, S., Wu, L. (2015) An unexplored diversity of reverse transcriptases in bacteria. Microbiology Spectrum. April 2015 3:2 doi:10.1128/microbiolspec.MDNA3-0058-2014en_US
dc.identifier.doi10.1128/microbiolspec.MDNA3-0058-2014
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/35158
dc.identifier.urihttp://hdl.handle.net/1880/51148
dc.language.isoenen_US
dc.publisherASMscienceen_US
dc.publisher.departmentBiological Sciencesen_US
dc.publisher.facultyScienceen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.publisher.urlhttp://www.asmscience.org/content/journal/microbiolspec/10.1128/microbiolspec.MDNA3-0058-2014en_US
dc.subjectBacterial proteinsen_US
dc.subjectGenetic elementsen_US
dc.subjectGroup II intronsen_US
dc.subjectDNA Polymerase IIIen_US
dc.titleAn unexplored diversity of reverse transcriptases in bacteriaen_US
dc.typejournal article
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