Catheter-Based Acoustic Interrogation Device for Monitoring Motility Dynamics of the Lower Esophageal Sphincter
| atmire.migration.oldid | 3764 | |
| dc.contributor.advisor | Mintchev, Martin | |
| dc.contributor.advisor | Yadid-Pecht, Orly | |
| dc.contributor.author | Lu, Qian | |
| dc.date.accessioned | 2015-09-30T20:33:13Z | |
| dc.date.available | 2015-11-20T08:00:44Z | |
| dc.date.issued | 2015-09-30 | |
| dc.date.submitted | 2015 | en |
| dc.description.abstract | Dysfunction of the lower esophageal sphincter (LES) could result in various gastrointestinal disorders.However, minimally-invasive technology for direct, long-term, ambulatory monitoring of the dynamics of the LES is lacking. This thesis aims at filling this void by presenting a novel, catheter-based acoustic interrogation device for real-time monitoring the motility dynamics of the LES. The device was first tested in-vitro on a custom-designed LES simulator. Measurements showed statistically significant Pearson correlation coefficients (p<0.05). In a pilot test on a canine model, the device successfully detected an episode in which the LES was forced opened and closed by a transoral endoscope, which was monitored by a second, transpyloric endoscope positioned in the distal stomach. The dynamics of the LES was independently confirmed by frame-by-frame endoscopic video analysis. The proposed acoustic catheter has the potential for facilitating the diagnosis of LES-related diseases. | en_US |
| dc.identifier.citation | Lu, Q. (2015). Catheter-Based Acoustic Interrogation Device for Monitoring Motility Dynamics of the Lower Esophageal Sphincter (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25228 | en_US |
| dc.identifier.doi | http://dx.doi.org/10.11575/PRISM/25228 | |
| dc.identifier.uri | http://hdl.handle.net/11023/2572 | |
| dc.language.iso | eng | |
| dc.publisher.faculty | Graduate Studies | |
| dc.publisher.institution | University of Calgary | en |
| dc.publisher.place | Calgary | en |
| dc.rights | University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission. | |
| dc.subject | Engineering--Biomedical | |
| dc.subject | Engineering--Electronics and Electrical | |
| dc.subject.classification | Catheter-Based | en_US |
| dc.subject.classification | Acoustic | en_US |
| dc.subject.classification | Microphone | en_US |
| dc.subject.classification | Oscillator | en_US |
| dc.subject.classification | Lower Esophageal Sphincter | en_US |
| dc.title | Catheter-Based Acoustic Interrogation Device for Monitoring Motility Dynamics of the Lower Esophageal Sphincter | |
| dc.type | master thesis | |
| thesis.degree.discipline | Electrical and Computer Engineering | |
| thesis.degree.grantor | University of Calgary | |
| thesis.degree.name | Master of Science (MSc) | |
| ucalgary.item.requestcopy | true |