Conductance and Capacitance Effects of Acute, Electrical, Carotid Baroreflex Stimulation

Simple item page
atmire.migration.oldid801
dc.contributor.advisorTyberg, John Victor
dc.contributor.authorBurgoyne, Steven John Joseph
dc.date.accessioned2013-04-16T21:39:49Z
dc.date.available2013-06-15T07:01:51Z
dc.date.issued2013-04-16
dc.date.submitted2013en
dc.description.abstractBaroreflex activation therapy (BAT) is effective in resistant hypertension; we hypothesized that BAT increases both venous capacitance and arterial conductance. We measured aortic pressure and flow and inferior vena caval flow and used a modified Brooksby-Donald technique to evaluate sub-diaphragmatic blood volume. Data were recorded with BAT, and with sodium nitroprusside (SNP) and Angiotensin II (Ang II) infusions, alone and with BAT. BAT substantially increased venous capacitance and arterial conductance. SNP also increased venous capacitance and arterial conductance. During SNP infusion BAT remained effective, further decreasing blood pressure and increasing capacitance and conductance. Ang II decreased both capacitance and conductance. During Ang II infusion, increased BAT reversed the decrease in venous capacitance while restoring BP completely and conductance to 80% of baseline. BAT decreases blood pressure and increases arterial conductance and venous capacitance, even when combined with powerful vasoactive drugs. These may be important effects in hypertension.en_US
dc.identifier.citationBurgoyne, S. J. (2013). Conductance and Capacitance Effects of Acute, Electrical, Carotid Baroreflex Stimulation (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25413en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/25413
dc.identifier.urihttp://hdl.handle.net/11023/604
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectAnimal Physiology
dc.subjectMedicine and Surgery
dc.subjectEngineering--Biomedical
dc.subject.classificationvenous capacitanceen_US
dc.subject.classificationbaroreflexen_US
dc.subject.classificationaortic conductanceen_US
dc.titleConductance and Capacitance Effects of Acute, Electrical, Carotid Baroreflex Stimulation
dc.typemaster thesis
thesis.degree.disciplineBiomedical Engineering
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ucalgary_2013_burgoyne_steven.pdf
Size:
1.37 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
2.65 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Open Theses and Dissertations