The Association Between Serum COMP Expression and Intra-articular Knee Injury Sustained 3-10 Years Previously in Youth Sport.

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atmire.migration.oldid4337
dc.contributor.advisorEmery, Carolyn
dc.contributor.advisorKrawetz, Roman
dc.contributor.authorLaudon, Jordan
dc.contributor.committeememberWhittaker, Jackie
dc.contributor.committeememberHart, David
dc.contributor.committeememberWoodhouse, Linda
dc.date.accessioned2016-05-03T17:13:39Z
dc.date.available2016-05-03T17:13:39Z
dc.date.issued2016
dc.date.submitted2016en
dc.description.abstractPurpose: This research investigates the relationship between knee injury and cartilage oligomeric matrix protein (COMP), a known indicator of joint deterioration in osteoarthritis (OA). Methods: 170 participants were recruited aged 16-26 years (85 with a sport-related intra-articular knee injury 3-10 years ago and 85 age, sex, and sport-matched controls). Serum samples were collected to evaluate COMP levels before and after physical activity. Results: Male participants averaged 15% greater (219.5 ng/ml, 95% CI 11.0–428.0, p = 0.04 serum COMP levels than uninjured controls. Female participants showed no significant elevation (9.8 ng/ml, 95% CI -208.4-227.9, p = 0.93). There were no differences between injured and uninjured participants in change in COMP pre to post exercise. Conclusions: This research demonstrated differences in baseline COMP values between participants based on history of knee injury in males only. Future research into specific knee injuries may yield insights in COMP’s value identifying risk of OA.en_US
dc.identifier.citationLaudon, J. (2016). The Association Between Serum COMP Expression and Intra-articular Knee Injury Sustained 3-10 Years Previously in Youth Sport. (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/28012en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/28012
dc.identifier.urihttp://hdl.handle.net/11023/2945
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.facultyKinesiology
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectAnthropology--Medical and Forensic
dc.subjectBiostatistics
dc.subjectMicrobiology
dc.subjectEpidemiology
dc.subject.classificationOsteoarthritisen_US
dc.subject.classificationPost-traumatic Osteoarthritisen_US
dc.subject.classificationCartilage Oligomeric Matrix Proteinen_US
dc.subject.classificationsporten_US
dc.subject.classificationinjuryen_US
dc.titleThe Association Between Serum COMP Expression and Intra-articular Knee Injury Sustained 3-10 Years Previously in Youth Sport.
dc.typemaster thesis
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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