Large-scale information processing during spontaneous brain activity revealed by cross-frequency coupling

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dc.contributor.advisorSotero Diaz, Roberto C.
dc.contributor.authorDousty, Mehdy
dc.contributor.committeememberBray, Signe Lauren
dc.contributor.committeememberPortzner, Andrea
dc.date2018-02
dc.date.accessioned2018-01-18T20:53:24Z
dc.date.available2018-01-18T20:53:24Z
dc.date.issued2017-12-19
dc.description.abstractAmplitude-amplitude (AAC), phase-phase (PPC), and phase-amplitude (PAC) coupling of brain activity are mechanisms that shape the information flow across multiple spatiotemporal scales; however, it is unclear how they are related. We used source-space projected resting-state magnetoencephalography data and empirical mode decomposition to obtain AAC-, PPC-, and PAC-based functional connectivity matrices. We found that specific PAC interactions are highly variable across subjects, but the global topological properties of the network are consistent. PPC and AAC were consistent at both the local and global scales. Additionally, the higher the spatial complexity of PAC is, the stronger its correlation with AAC and PPC will be. Finally, direct and indirect functional connections are differently correlated to the properties of the underlying anatomical scaffold. Together, our results suggest that PPC of high frequencies facilitates the integration of information, AAC of low frequencies facilitates the segregation of information, and PAC is the mechanism binding these two information streams.en_US
dc.identifier.citationDousty, M. (2017). Large-scale information processing during spontaneous brain activity revealed by cross-frequency coupling (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/5356
dc.identifier.urihttp://hdl.handle.net/1880/106275
dc.language.isoenen_US
dc.publisher.facultySchulich School of Engineeringen_US
dc.publisher.institutionUniversity of Calgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.en_US
dc.subjectCross frequency couplingen_US
dc.subjectPhase Phase couplingen_US
dc.subjectAmplitude Amplitude couplingen_US
dc.subjectFunctional connectivityen_US
dc.subjectAnatomical connectivityen_US
dc.subjectEmpirical Mode Decompositionen_US
dc.subject.classificationNeuroscienceen_US
dc.titleLarge-scale information processing during spontaneous brain activity revealed by cross-frequency couplingen_US
dc.typemaster thesisen_US
thesis.degree.disciplineEngineering – Biomedicalen_US
thesis.degree.grantorUniversity of Calgaryen_US
thesis.degree.nameMaster of Science (MSc)en_US
ucalgary.item.requestcopytrue
ucalgary.thesis.checklistI confirm that I have submitted all of the required forms to Faculty of Graduate Studies.en_US
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