Development of an Artificial Pancreas: Control of Glucose in Type 1 Diabetics Using Model Predictive Control with a Low Order Model

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dc.contributor.advisorPieper, Jeff
dc.contributor.authorFrayne, Mark Christopher Hill
dc.contributor.committeememberWestwick, David
dc.contributor.committeememberBisheban, Mahdis
dc.date2024-11
dc.date.accessioned2024-06-17T14:50:00Z
dc.date.available2024-06-17T14:50:00Z
dc.date.issued2024-06-13
dc.description.abstractType one diabetes is an autoimmune disorder that causes people to not produce hormones that govern glucose control, which can lead to many health issues. The current treatment for this disorder is the injection of insulin either manually or with a preprogramed pump. An artificial pancreas is a device that aims to improve this treatment by connecting the pump to a glucose sensor and feedback controller to automatically adjust the injection rate. This project proposes the use of Model Predictive Control (MPC) to close this loop. MPC was implemented using a low-order linear model of the human glucose system and applied to simple human kinetic models as well as a higher-order complex plant. In both cases the controller was able to significantly reduce the maximum glucose levels along with time-integrated excursion measures. In realistic simulations modelling human physiology, maximum hyperglycemia was reduced from 174 mg/dL to 120 mg/dL when a disturbance of 100g of carbohydrates was applied.
dc.identifier.citationFrayne, M. C. H. (2024). Development of an artificial pancreas: control of glucose in type 1 diabetics using model predictive control with a low order model (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.
dc.identifier.urihttps://hdl.handle.net/1880/118948
dc.language.isoen
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgary
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectModel Predictive Control
dc.subjectArtificial Pancreas
dc.subjectType 1 Diabetes
dc.subject.classificationEngineering--Mechanical
dc.subject.classificationEngineering--Biomedical
dc.titleDevelopment of an Artificial Pancreas: Control of Glucose in Type 1 Diabetics Using Model Predictive Control with a Low Order Model
dc.typemaster thesis
thesis.degree.disciplineEngineering – Mechanical & Manufacturing
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.thesis.accesssetbystudentI do not require a thesis withhold – my thesis will have open access and can be viewed and downloaded publicly as soon as possible.
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