The Effects of Diet and Ultra Violet B Exposure on Vitamin D Levels and Muscle Performance In Mice (Mus musculus)

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dc.contributor.advisorSyme, Douglas A.
dc.contributor.authorTsao, Natalie
dc.contributor.committeememberBarclay, Robert M. R.
dc.contributor.committeememberBurton, Jodie M.
dc.date2019-11
dc.date.accessioned2019-09-19T20:39:28Z
dc.date.available2019-09-19T20:39:28Z
dc.date.issued2019-09-17
dc.description.abstractVitamin D is a steroid that promotes healthy bone structure and muscle function. It is obtained from the diet and synthesized in the skin during UV-B exposure from sunlight. In muscle, it influences calcium transport and promotes growth, with varied responses depending on muscle type. I hypothesized that reduced vitamin D in the diet and removal of UVB light, as occurs during hibernation or the Polar winter, will impact circulating levels of vitamin D to the extent that muscle contractile performance is altered. I also hypothesize that fast-twitch muscles will show greater responses of muscle contractile capabilities to treatments compared to slow-twitch muscles. Mice were used as a model, and fed diets with normal or low vitamin D, and exposed to normal or no UV-B doses for 3 months. Neither fast nor slow muscle types showed significant differences between treatment groups in force, power, force-velocity measures, or rates of fatigue. Serum vitamin D levels, measured at the midpoint and endpoint of the treatment, varied substantially among individuals, but not, on average, among treatment groups, indicating mechanisms of compensatory homeostasis in the face of reduced vitamin D supply. These results suggest that intermittent interruptions in dietary vitamin D or light exposure in mammals, such as those that hibernate or live above the Arctic Circle, do not impair muscle contractile function.en_US
dc.identifier.citationTsao, N. (2019). The Effects of Diet and Ultra Violet B Exposure on Vitamin D Levels and Muscle Performance In Mice (Mus musculus) (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/37082
dc.identifier.urihttp://hdl.handle.net/1880/111017
dc.language.isoengen_US
dc.publisher.facultyScienceen_US
dc.publisher.institutionUniversity of Calgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.en_US
dc.subjectMiceen_US
dc.subjectVitamin Den_US
dc.subjectMuscle Performanceen_US
dc.subjectFast-twitch Musclesen_US
dc.subjectSlow-twitch Musclesen_US
dc.subjectUltraviolet Ben_US
dc.subject.classificationEducation--Healthen_US
dc.subject.classificationAnimal Pathologyen_US
dc.subject.classificationFood Science and Technologyen_US
dc.subject.classificationAnimal Physiologyen_US
dc.subject.classificationPhysiologyen_US
dc.subject.classificationVeterinary Scienceen_US
dc.subject.classificationZoologyen_US
dc.titleThe Effects of Diet and Ultra Violet B Exposure on Vitamin D Levels and Muscle Performance In Mice (Mus musculus)en_US
dc.typemaster thesisen_US
thesis.degree.disciplineBiological Sciencesen_US
thesis.degree.grantorUniversity of Calgaryen_US
thesis.degree.nameMaster of Science (MSc)en_US
ucalgary.item.requestcopytrueen_US
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