Characterization of the Dedifferentiated Schwann Cell and Development of a Deprogramming-Strategy to Enhance Their Regenerative Capacity

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atmire.migration.oldid4673
dc.contributor.advisorBiernaskie, Jeff
dc.contributor.authorStykel, Morgan
dc.contributor.committeememberOusman, Shalina
dc.contributor.committeememberWhelan, Patrick
dc.contributor.committeememberSchuurmans, Carol
dc.contributor.committeememberChan, Jennifer
dc.date.accessioned2016-07-22T21:48:41Z
dc.date.available2016-07-22T21:48:41Z
dc.date.issued2016
dc.date.submitted2016en
dc.description.abstractA striking feature of the peripheral nervous system is the ability to regenerate; this ability is, in part, due to the Schwann cell, the glial cell of the periphery. Following peripheral injury, Schwann cells up-regulate a battery of proteins, many of which are re-expressed from development, that drive the efficient regenerative response in the peripheral nervous system. My work described in this thesis characterizes the gene expression profile driving this regenerative response as well as factors implicated during Schwann cell development. Then, I began to develop a deprogramming-based approach to modulate the Schwann cell phenotype by overexpressing the factors of interest. I optimized a deprogramming strategy that can be used to further elucidate the functional contribution of various transcription factors in adult Schwann cells. This can also enhance Schwann cell function following circumstances such prolonged denervation, disease, or advanced aged which often results in impaired regenerative function.en_US
dc.identifier.citationStykel, M. (2016). Characterization of the Dedifferentiated Schwann Cell and Development of a Deprogramming-Strategy to Enhance Their Regenerative Capacity (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25292en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/25292
dc.identifier.urihttp://hdl.handle.net/11023/3150
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectNeuroscience
dc.subject.classificationSchwann cellen_US
dc.subject.classificationTranscription Factorsen_US
dc.subject.classificationReprogrammingen_US
dc.subject.classificationPeripheral Nerve Injuryen_US
dc.subject.classificationRegenerationen_US
dc.subject.classificationPNSen_US
dc.titleCharacterization of the Dedifferentiated Schwann Cell and Development of a Deprogramming-Strategy to Enhance Their Regenerative Capacity
dc.typemaster thesis
thesis.degree.disciplineNeuroscience
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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