Reaction of dirhodium(II) tetraacetate with S-methyl-L-cysteine

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dc.contributor.authorBrunskill, Valerie
dc.contributor.authorEnriquez Garcia, Alejandra
dc.contributor.authorJalilehvand, Farideh
dc.contributor.authorGelfand, Benjamin S.
dc.contributor.authorWu, Mengya
dc.date.accessioned2021-07-30T17:18:36Z
dc.date.embargolift2020-08-12
dc.date.issued2019-08-12
dc.descriptionThis is an Accepted Manuscript of an article published by Taylor & Francis in Journal of Coordination Chemistry on 2019-08-12, available online: http://www.tandfonline.com/10.1080/00958972.2019.1651845.
dc.description.abstractThe reaction of antitumor active dirhodium(II) tetraacetate, [Rh2(AcO)4], with S-methyl-L-cysteine (HSMC) was studied at the pH of mixing (=4.8) in aqueous media at various temperatures under aerobic conditions. The results from UV–vis spectroscopy and electrospray ionization mass spectrometry (ESI–MS) showed that HSMC initially coordinates via its sulfur atom to the axial positions of the paddlewheel framework of the dirhodium(II) complex, and was confirmed by the crystal structure of [Rh2(AcO)4(HSMC)2]. After some time (48?h at 25?°C), or at elevated temperature (40?°C), Rh-SMC chelate formation causes breakdown of the paddlewheel structure, generating the mononuclear Rh(III) complexes [Rh(SMC)2]+, [Rh(AcO)(SMC)2] and [Rh(SMC)3], as indicated by ESI–MS. These aerobic reaction products of [Rh2(AcO)4] with HSMC have been compared with those of the two proteinogenic sulfur-containing amino acids methionine and cysteine. Comparison shows that the (S,N)-chelate ring size influences the stability of the [Rh2(AcO)4] paddlewheel cage structure and its RhII–RhII bond, when an amino acid with a thioether group coordinates to dirhodium(II) tetraacetate.
dc.identifier.citationBrunskill, V., Enriquez Garcia, A., Jalilehvand, F., Gelfand, B. S., & Wu, M. (2019). Reaction of dirhodium(II) tetraacetate withS-methyl-L-cysteine. Journal of Coordination Chemistry, 72(13), 2177–2188. doi:10.1080/00958972.2019.1651845
dc.identifier.doi10.1080/00958972.2019.1651845
dc.identifier.issn1029-0389
dc.identifier.urihttp://hdl.handle.net/1880/113676
dc.identifier.urihttps://dx.doi.org/10.11575/PRISM/39047
dc.language.isoenen
dc.language.isoeng
dc.publisherTaylor & Francis
dc.publisher.departmentChemistry
dc.publisher.facultyScienceen
dc.publisher.hasversionPost-print
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.policyhttps://authorservices.taylorandfrancis.com/research-impact/sharing-versions-of-journal-articles/#acceptedmanuscript
dc.rightsUnless otherwise indicated, this material is protected by copyright and has been made available with authorization from the copyright owner. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.en
dc.subjectDirhodium(II) tetraacetate
dc.subjectS-methyl-L-cysteine
dc.subjectESI–MS
dc.subjectUV–vis spectroscopy
dc.subjectcrystal structure
dc.titleReaction of dirhodium(II) tetraacetate with S-methyl-L-cysteine
dc.typejournal article
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