A novel three-filament model of force generation in eccentric contraction of skeletal muscles

Schappacher-Tilp, Gudrun; Leonard, Timothy R.; Desch, Gertrud Wolfgang; Herzog, Walter

A novel three-filament model of force generation in eccentric contraction of skeletal muscles

Files

042_SChappacher-Tilp_2016_Novel_PLOSone.pdf(2.72 MB)

Date

2015-01

Authors

Schappacher-Tilp, Gudrun

Leonard, Timothy R.

Desch, Gertrud Wolfgang

Herzog, Walter

Publisher

PLOS One

Abstract

We propose and examine a three filament model of skeletal muscle force generation, thereby extending classical cross-bridge models by involving titin-actin interaction upon active force production. In regions with optimal actin-myosin overlap, the model does not alter energy and force predictions of cross-bridge models for isometric contractions. However, in contrast to cross-bridge models, the three filament model accurately predicts history-dependent force generation in half sarcomeres for eccentric and concentric contractions, and predicts the activation-dependent forces for stretches beyond actin-myosin filament overlap.

Citation

Schappacher-Tilp, G., Leonard, T., Desch, G., & Herzog, W. (2015). A Novel Three-Filament Model of Force Generation in Eccentric Contraction of Skeletal Muscles. PLOS ONE, 10(3), e0117634. https://doi.org/10.1371/journal.pone.0117634

URI

http://hdl.handle.net/1880/107776

Collections

Kinesiology Research & Publications

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