Measuring Brain Connectivity and Hemodynamic Alterations Following Pediatric Mild Traumatic Brain Injury in the Primary Motor Cortex

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dc.contributor.advisorDunn, Jeffrey Frank
dc.contributor.advisorBarlow, Karen Maria
dc.contributor.authorUrban, Karolina
dc.date.accessioned2015-01-08T16:14:24Z
dc.date.available2015-02-23T08:00:38Z
dc.date.issued2015-01-08
dc.date.submitted2014en
dc.description.abstractConcussion, or mild traumatic brain injury, is a growing concern especially among the pediatric population. Symptoms may persist beyond one month after injury and result in long term disability called Post-Concussion Syndrome (PCS). There is a lack of measures to quantitatively monitor and explore pathophysiological mechanisms of PCS. We hypothesized that since fiber tracts are often impacted in concussion, functional activation and inter-hemispheric brain communication may be impaired. We used functional near-infrared spectroscopy (fNIRS) to quantify the magnitude of activation and inter-hemispheric communication between motor cortices using a coherence analysis. Subjects completed a resting state and tapping paradigm. We detected differences between patients and controls in coherence, suggesting alterations in inter-hemispheric communication. Given the critical need for a quantitative biomarker for recovery following a concussion, we present this data to highlight the potential of fNIRS, coupled with coherence analysis, as a sensitive measure to detect functional changes.en_US
dc.identifier.citationUrban, K. (2015). Measuring Brain Connectivity and Hemodynamic Alterations Following Pediatric Mild Traumatic Brain Injury in the Primary Motor Cortex (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26855en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/26855
dc.identifier.urihttp://hdl.handle.net/11023/1991
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectNeuroscience
dc.subject.classificationConcussionen_US
dc.subject.classificationmild traumatic brain injuryen_US
dc.subject.classificationfunctional near infrared spectroscopyen_US
dc.subject.classificationoptical imagingen_US
dc.subject.classificationfunctional connectivityen_US
dc.subject.classificationCoherenceen_US
dc.titleMeasuring Brain Connectivity and Hemodynamic Alterations Following Pediatric Mild Traumatic Brain Injury in the Primary Motor Cortex
dc.typemaster thesis
thesis.degree.disciplineNeuroscience
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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