A Bioinformatics Analysis to Identify Parasite Proteins that Mimic Host Immune Proteins

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atmire.migration.oldid5222
dc.contributor.advisorWasmuth, James
dc.contributor.advisorMcKay, Derek
dc.contributor.authorSrivastava, Shruti
dc.contributor.committeememberMelin, Amanda
dc.contributor.committeememberGilch, Sabine
dc.contributor.committeememberde Koning, Jason
dc.date.accessioned2017-01-04T16:04:44Z
dc.date.available2017-01-04T16:04:44Z
dc.date.issued2016
dc.date.submitted2016en
dc.description.abstractParasitic helminths (worms) are major parasites of humans and livestock around the world. These helminths are usually long lived and cause chronic infections, which invoke immune responses in the host leading to pathological changes. These changes are not always considered negative. For example, a helminth infection often leads to a shift in the host immune system away from inflammation. As such, some people with severe auto-immune diseases have experienced remission when infected with helminths. Examples include inflammatory bowel diseases. This `helminth-therapy' is controversial, but motivates a better understanding of helminth-host interactions. Previous work has shown that parasites encode proteins within their genomes which are secreted into their host, which modulate the host immune system. However, proteomic based studies have not identified the proteins involved. Here, we are taking a bioinformatics and genomics approach to discover the key proteins.en_US
dc.identifier.citationSrivastava, S. (2016). A Bioinformatics Analysis to Identify Parasite Proteins that Mimic Host Immune Proteins (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/24633en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/24633
dc.identifier.urihttp://hdl.handle.net/11023/3537
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.facultyVeterinary Medicine
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectBioinformatics
dc.subjectParasitology
dc.subjectVeterinary Science
dc.subjectImmunology
dc.subjectPublic Health
dc.subject.classificationBioinformaticsen_US
dc.subject.classificationMolecular mimicryen_US
dc.subject.classificationImmunomodulationen_US
dc.subject.classificationHelminthsen_US
dc.subject.classificationSequence similarityen_US
dc.titleA Bioinformatics Analysis to Identify Parasite Proteins that Mimic Host Immune Proteins
dc.typemaster thesis
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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