Exploring Mitochondrial Regulation of Reovirus Infection in Cancer Cells

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dc.contributor.advisorJohnston, Randal
dc.contributor.authorClarkson, Matthew
dc.date.accessioned2014-09-30T22:05:58Z
dc.date.available2014-11-17T08:00:52Z
dc.date.issued2014-09-30
dc.date.submitted2014en
dc.description.abstractOncolytic reovirus demonstrates mixed results in clinical trials. To achieve better clinical outcomes a more complete understanding of reovirus infection is needed. Efficient reovirus infection often culminates in cell death by apoptosis. Mitochondria play essential roles regulating apoptosis and oxidative phosphorylation. Although mitochondria are implicated in integrating reovirus-induced apoptotic signaling, no study has explored how modulating apoptotic pathways or mitochondrial metabolism influences reovirus infection. I demonstrate that directly priming apoptotic pathways may be an effective strategy for augmenting reovirus-induced cytolysis in pediatric leukemia cells and possibly other cancer cells. Further study is warranted to explore the clinical potential of this strategy. The experiments attempting to modulate mitochondrial function may be consistent with a role for mitochondrial respiration in reovirus infection. However, the influence of mitochondrial metabolism on reovirus infection requires more directed study in the future.en_US
dc.identifier.citationClarkson, M. (2014). Exploring Mitochondrial Regulation of Reovirus Infection in Cancer Cells (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26090en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/26090
dc.identifier.urihttp://hdl.handle.net/11023/1891
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectBiology--Cell
dc.subjectBiology--Molecular
dc.subjectVirology
dc.subject.classificationReovirusen_US
dc.subject.classificationMitochondriaen_US
dc.subject.classificationcanceren_US
dc.titleExploring Mitochondrial Regulation of Reovirus Infection in Cancer Cells
dc.typemaster thesis
thesis.degree.disciplineBiochemistry and Molecular Biology
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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