A real-time assessment of the relationship between neuronal activation and hemodynamic changes in humans

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dc.contributor.advisorSmirl, Jonathan
dc.contributor.advisorDunn, Jeffrey
dc.contributor.authorBurma, Joel Stephen
dc.contributor.committeememberSchneider, Kathryn
dc.contributor.committeememberDebert, Chantel
dc.date2024-11
dc.date.accessioned2024-09-04T17:11:06Z
dc.date.available2024-09-04T17:11:06Z
dc.date.issued2024-08-29
dc.description.abstractThis dissertation aimed to develop and employ a novel multimodal neuroimaging approach utilizing electroencephalography (EEG), functional near-infrared spectroscopy (fNIRS), transcranial Doppler ultrasound (TCD), finger photoplethysmography, electrocardiography, and capnography to study neurological, cerebrovascular, and cardiorespiratory responses during motor and visual tasks. The dissertation adopted a step-by-step approach for method development. Initially, a thorough systematic review of previous multimodal neuroimaging studies investigating neurovascular coupling/functional hyperemia was conducted to identify common limitations and equipment combinations (Chapter 2). This review informed the development of a novel concurrent integration of EEG-fNIRS-TCD neuromonitoring techniques with systemic physiological monitoring, detailed in Chapter 3. Following this, a pilot study involving 15 participants was conducted to assess the data quality from the three imaging modalities during resting motor (finger tapping) and visual (“Where’s Waldo/Wally?”) tasks (Chapter 4). These tasks were then performed during transient blood pressure oscillations induced by squat-stand maneuvers at 0.05 and 0.10 Hz to challenge the cerebrovasculature (Chapter 5), demonstrating that the neurovascular coupling task remained stable despite significant blood pressure fluctuations. Overall, the findings from this dissertation underscore the robustness of the EEG-fNIRS-TCD approach in capturing neuronal and cerebral hemodynamic responses across various tasks and hemodynamic challenges, providing better insight into cerebrovascular regulation.
dc.identifier.citationBurma, J. S. (2024). A real-time assessment of the relationship between neuronal activation and hemodynamic changes in humans (Doctoral thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.
dc.identifier.urihttps://hdl.handle.net/1880/119597
dc.language.isoen
dc.publisher.facultyArts
dc.publisher.institutionUniversity of Calgary
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectNeuroscience
dc.subjectCerebrovascular Physiology
dc.subject.classificationEngineering--Biomedical
dc.titleA real-time assessment of the relationship between neuronal activation and hemodynamic changes in humans
dc.typedoctoral thesis
thesis.degree.disciplineKinesiology
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameDoctor of Philosophy (PhD)
ucalgary.thesis.accesssetbystudentI do not require a thesis withhold – my thesis will have open access and can be viewed and downloaded publicly as soon as possible.
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