Predicting Post-Operative Functional Performance, Treatment Path, and Overall Survival in Glioblastoma Patients based on Tumour Location and Size

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atmire.migration.oldid4357
dc.contributor.advisorFrayne, Richard
dc.contributor.authorLi, Luca Yangyang
dc.contributor.committeememberStell, William Kenyon
dc.contributor.committeememberGoodyear, Bradley Gordon
dc.contributor.committeememberGobbi, David
dc.contributor.committeememberEasaw, Jacob Chirakkattu
dc.date.accessioned2016-05-04T16:00:16Z
dc.date.available2016-05-04T16:00:16Z
dc.date.issued2016
dc.date.submitted2016en
dc.description.abstractGlioblastoma multiforme (GBM) is the most common primary brain malignancy in adults with a median survival of 12-18 months with treatment. Surgical reduction of the tumour volume by 78% or more increases patient life expectancy (further extended by adjuvant radio/chemotherapy). Although GBM surgery focuses on complete removal of the tumour, there is limited evidence supporting the approach, and the question of what effect the extent-ofresection (EOR) has on patient prognosis is frequently asked. Furthermore, extensive surgery in GBM management has been associated with surgically-acquired motor and language deficits. In addition, present subjective appraisals of tumour severity based on location are inconsistent. Working towards an objective grading system with radiological markers has been suggested to improve accuracy. In this thesis, I demonstrate a quantitative approach for assessing tumour severity. These results provide more evidence for tumour anatomical location and size as factors in affecting post-surgical functional performance and predicting clinical response.en_US
dc.identifier.citationLi, L. Y. (2016). Predicting Post-Operative Functional Performance, Treatment Path, and Overall Survival in Glioblastoma Patients based on Tumour Location and Size (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/27403en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/27403
dc.identifier.urihttp://hdl.handle.net/11023/2959
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectNeuroscience
dc.subjectEngineering--Biomedical
dc.subject.classificationGlioblastoma Multiformeen_US
dc.subject.classificationMagnetic Resonance Imagingen_US
dc.subject.classificationExtent-of-Resectionen_US
dc.subject.classificationBrain Tumouren_US
dc.subject.classificationKarnofsky Performance Scaleen_US
dc.titlePredicting Post-Operative Functional Performance, Treatment Path, and Overall Survival in Glioblastoma Patients based on Tumour Location and Size
dc.typemaster thesis
thesis.degree.disciplineBiomedical Engineering
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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