Activity Dependent Changes to Astrocyte Resting Calcium

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atmire.migration.oldid4261
dc.contributor.advisorGordon, Grant
dc.contributor.authorMehina, Eslam
dc.contributor.committeememberPittman, Quentin
dc.contributor.committeememberThompson, Roger
dc.date.accessioned2016-04-25T21:34:23Z
dc.date.available2016-04-25T21:34:23Z
dc.date.issued2016
dc.date.submitted2016en
dc.description.abstractThe majority of research regarding astrocyte calcium responses has focused on large transients produced in response to stimulation, while little is known about the regulation and role of resting calcium levels. Recent findings suggest that resting astrocyte calcium provides tonic regulation of nearby arterioles, emphasizing the importance of investigating this factor. Here we examine the effects of specific patterns of synaptic activity, specifically theta burst stimulation, on resting astrocyte calcium levels. We observed a significant, long-lasting decrease in resting calcium concentrations in these cells following stimulation, an effect that was inhibited by ionotropic and metabotropic glutamate receptor antagonists. This decrease in resting calcium levels was not observed in neurons, and may be involved in eliciting the vasoconstriction of nearby vessels observed following stimulation. These results demonstrate a novel calcium response in astrocytes that may be relevant to the physiological roles of these glial cells in the neurovascular unit.en_US
dc.identifier.citationMehina, E. (2016). Activity Dependent Changes to Astrocyte Resting Calcium (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/24694en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/24694
dc.identifier.urihttp://hdl.handle.net/11023/2901
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectNeuroscience
dc.subject.classificationresting calciumen_US
dc.subject.classificationneurovascular couplingen_US
dc.subject.classificationastrocyteen_US
dc.subject.classificationNeuronen_US
dc.subject.classificationglutamatergic signallingen_US
dc.titleActivity Dependent Changes to Astrocyte Resting Calcium
dc.typemaster thesis
thesis.degree.disciplineNeuroscience
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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