Experience-Dependent Modulation of Adult Hippocampal Neurogenesis in Female Mice

Simple item page
atmire.migration.oldid4476
dc.contributor.advisorDyck, Richard
dc.contributor.authorBoon, Jacqueline
dc.contributor.committeememberAntle, Michael
dc.contributor.committeememberLovic, Vedran
dc.contributor.committeememberKurrasch, Deborah
dc.date.accessioned2016-06-03T16:49:40Z
dc.date.available2016-06-03T16:49:40Z
dc.date.issued2016
dc.date.submitted2016en
dc.description.abstractThe capacity of the mature adult brain to adapt following experience is limited. One means by which the adult brain can undergo plastic change is through the generation of new neurons, a process referred to as neurogenesis. Adult hippocampal neurogenesis (AHN) occurs in the subgranular zone of the dentate gyrus, can be modulated by experience, and has important implications for learning/memory and disease treatment. Experiences rarely occur in isolation and understanding the interacting effects of several modulators is necessary to fully harness potential therapeutic effects of AHN. We examined the combined effects of several modulators including chronic perinatal and adulthood exposure to selective serotonin reuptake inhibitor fluoxetine, social isolation, synaptic zinc and environmental enrichment. Our results emphasize the complexity of modulation of AHN by experience, suggest that synaptic zinc is necessary for the positive modulation of AHN, and imply that this process may be maximally modulated in the hippocampus.en_US
dc.identifier.citationBoon, J. (2016). Experience-Dependent Modulation of Adult Hippocampal Neurogenesis in Female Mice (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26043en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/26043
dc.identifier.urihttp://hdl.handle.net/11023/3041
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectNeuroscience
dc.subjectMental Health
dc.subjectPharmacology
dc.subjectPsychology--Experimental
dc.subject.classificationneurogenesisen_US
dc.subject.classificationFluoxetineen_US
dc.subject.classificationzincen_US
dc.subject.classificationBehaviouren_US
dc.subject.classificationDevelopmenten_US
dc.subject.classificationDepressionen_US
dc.subject.classificationNeuroplasticityen_US
dc.titleExperience-Dependent Modulation of Adult Hippocampal Neurogenesis in Female Mice
dc.typemaster thesis
thesis.degree.disciplinePsychology
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
Files
Collections
Open Theses and Dissertations