Effect of macrophage depletion on avian infectious bronchitis coronavirus infection

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atmire.migration.oldid1988
dc.contributor.advisorCareem, Mohammad Faizal Abdul
dc.contributor.authorKameka, Amber Marie
dc.date.accessioned2014-04-04T16:17:19Z
dc.date.available2014-06-16T07:00:27Z
dc.date.issued2014-04-04
dc.date.submittedAPRIL, 2014en
dc.description.abstractInfectious bronchitis virus (IBV) causes severe respiratory tract infections in young chickens and has significant negative impact on the poultry industry. Information on the functional roles of macrophages in response to IBV infection is scarce. Objectives of the work described in the thesis were to 1) establish an effective means of depleting macrophages within the respiratory tract of chickens using clodronate encapsulated-liposomes, 2) determine the effects of IBV infection on macrophage numbers in vivo, and 3) the effect of macrophage depletion on the replication of IBV and resulting pathogenesis. We found that clodronate encapsulated-liposomes were effective in significantly depleting macrophages in the respiratory tract. We also observed that an infection with the Conn strain IBV results in an increase in macrophage numbers in trachea and lung, and that clodronate encapsulated-liposome treated trachea have a higher IBV genome load at the beginning of infection when compared to untreated tissues. Our data suggests that respiratory macrophages may play an important role in limiting the replication of IBV within respiratory tissues.en_US
dc.identifier.citationKameka, A. M. (2014). Effect of macrophage depletion on avian infectious bronchitis coronavirus infection (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25802en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/25802
dc.identifier.urihttp://hdl.handle.net/11023/1402
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.facultyVeterinary Medicine
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectAnimal Physiology
dc.subjectVirology
dc.subjectImmunology
dc.subject.classificationmacrophageen_US
dc.subject.classificationinfectious bronchitis virusen_US
dc.subject.classificationchickenen_US
dc.titleEffect of macrophage depletion on avian infectious bronchitis coronavirus infection
dc.typemaster thesis
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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