Effect of Prebiotic Fiber Intake on Adiposity and Inflammation in Overweight and Obese Children: Assessing the Role of the Gut Microbiota

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atmire.migration.oldid3583
dc.contributor.advisorReimer, Raylene
dc.contributor.authorNicolucci, Alissa
dc.date.accessioned2015-09-18T21:10:25Z
dc.date.available2015-11-20T08:00:40Z
dc.date.issued2015-09-18
dc.date.submitted2015en
dc.description.abstractPediatric obesity is a serious national and global health challenge. Interventions aimed at improving obesity and its metabolic complications in children are critically needed. The aim of this thesis was to assess the effects of 16 weeks of oligofructose-enriched inulin consumption on overweight and obese children 7-12 years old. Compared to placebo, prebiotic fiber consumption normalized body weight gain and significantly reduced body weight Z-score, total body fat and trunk body fat percent. Inflammatory markers interleukin-6 and C-reactive protein were numerically reduced within the prebiotic fiber group, albeit not statistically significantly. Changes in the gut microbiota, specifically significant increases in Bifidobacterium spp., were observed with prebiotic fiber and may represent, a mechanism for the metabolic benefits of prebiotic fiber consumption. While future studies are needed, this work highlights a promising role for prebiotic fiber as a dietary obesity intervention in the pediatric population.en_US
dc.identifier.citationNicolucci, A. (2015). Effect of Prebiotic Fiber Intake on Adiposity and Inflammation in Overweight and Obese Children: Assessing the Role of the Gut Microbiota (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25803en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/25803
dc.identifier.urihttp://hdl.handle.net/11023/2469
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.facultyKinesiology
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectMicrobiology
dc.subjectNutrition
dc.subject.classificationPrebiotic Fiberen_US
dc.subject.classificationPediatricsen_US
dc.subject.classificationObesityen_US
dc.subject.classificationGut Microbiotaen_US
dc.subject.classificationOligofructose-enriched Inulinen_US
dc.subject.classificationInflammationen_US
dc.titleEffect of Prebiotic Fiber Intake on Adiposity and Inflammation in Overweight and Obese Children: Assessing the Role of the Gut Microbiota
dc.typemaster thesis
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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