Intranasal Insulin for Treatment of Diabetic Polyneuropathy

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atmire.migration.oldid1618
dc.contributor.advisorWiebe, Samuel
dc.contributor.advisorJetté, Nathalie
dc.contributor.authorKorngut, Lawrence
dc.date.accessioned2013-11-19T17:04:13Z
dc.date.available2014-03-15T07:00:15Z
dc.date.issued2013-11-19
dc.date.submitted2013en
dc.description.abstractIntranasal insulin administration is a novel approach to slow the progression of diabetic polyneuropathy (DPN). We performed a pilot randomized controlled trial of intranasal insulin in 12 type 1 diabetes mellitus patients with DPN to assess safety. We administered intranasal insulin for 6 weeks using biweekly dose-escalation up to 160 IU/d or intranasal saline. The primary outcome measure was frequency of hypoglycaemia. Frequency of mild (mHG) and serious hypoglycaemic (sHG) events was recorded. Secondary outcomes included clinical (Utah Early Neuropathy Score (UENS)) and laboratory (corneal confocal microscopy and electrophysiology) measures. There were no differences in glycemia between groups after supervised initial administration. The 40 IU/d and 80 IU/d doses were safe and well tolerated with comparable mHG events between groups. One intranasal insulin subject suffered a sHG at home while receiving 160 IU/d. Intranasal insulin was safe and well tolerated at 40 and 80 IU/d.en_US
dc.identifier.citationKorngut, L. (2013). Intranasal Insulin for Treatment of Diabetic Polyneuropathy (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26624en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/26624
dc.identifier.urihttp://hdl.handle.net/11023/1163
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectNeuroscience
dc.subjectMedicine and Surgery
dc.subjectPharmacology
dc.subject.classificationDiabetesen_US
dc.subject.classificationInsulinen_US
dc.subject.classificationtreatmenten_US
dc.subject.classificationNeuropathyen_US
dc.titleIntranasal Insulin for Treatment of Diabetic Polyneuropathy
dc.typemaster thesis
thesis.degree.disciplineCommunity Health Sciences
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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