Sleep Disturbances and Fatigue in Survivors of Pediatric Acute Lymphoblastic Leukemia and their Siblings

Russell, Karleen Brooke

Sleep Disturbances and Fatigue in Survivors of Pediatric Acute Lymphoblastic Leukemia and their Siblings

dc.contributor.advisor	Tomfohr-Madsen, Lianne M.
dc.contributor.advisor	Schulte, Fiona S. M.
dc.contributor.author	Russell, Karleen Brooke
dc.contributor.committeemember	Noel, Melanie
dc.contributor.committeemember	Brooks, Brian L.
dc.contributor.committeemember	Laing, Catherine M.
dc.date	2019-11
dc.date.accessioned	2019-08-20T15:14:10Z
dc.date.available	2019-08-20T15:14:10Z
dc.date.issued	2019-08-19
dc.description.abstract	Sleep disturbances and fatigue have been identified by patients with cancer as common and distressing. Conflicting evidence about the prevalence of these outcomes, however, exists for survivors of childhood cancers. Additionally, little is known about how the cancer trajectory might impact survivor siblings’ sleep and fatigue. The current study compared sleep and fatigue in survivors of acute lymphoblastic leukemia (ALL) (2-7 years off therapy) and their siblings to healthy control sibling dyads. We hypothesized that survivors would have less total sleep time (TST), greater wake after sleep onset (WASO), poorer sleep efficiency (SE), and higher ratings of fatigue than controls. Participants (survivors, n=45; survivor siblings, n=27; controls, n=45; control siblings, n=41; 58% male) aged 8-18 (m=11.64, SD=2.62) completed the PedsQL Multidimensional Fatigue Scale, a 7-day sleep diary, and 7-consecutive days of actigraphy. Parents (n=90) completed the Children’s Sleep Habits Questionnaire for each of their children. No between-group differences were found on measures of fatigue, sleep diaries, or actigraphy. Parents reported that survivor siblings had significantly poorer sleep habits than survivors or controls. For survivors, greater time off treatment and younger age at diagnosis were significantly related to poorer outcomes via actigraphy on TST, WASO, and SE, as well as sleep-onset latency (SOL) via sleep diaries. This research suggests that poorer sleep in later survivorship from childhood cancer may be related to late-effects, which may account for variability in these findings in the broader literature, and that siblings of survivors of childhood cancer may be at risk for sleep problems.	en_US
dc.identifier.citation	Russell, K. B. (2019). Sleep Disturbances and Fatigue in Survivors of Pediatric Acute Lymphoblastic Leukemia and their Siblings (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.	en_US
dc.identifier.doi	http://dx.doi.org/10.11575/PRISM/36836
dc.identifier.uri	http://hdl.handle.net/1880/110749
dc.language.iso	eng	en_US
dc.publisher.faculty	Arts	en_US
dc.publisher.institution	University of Calgary	en
dc.rights	University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.	en_US
dc.subject	Childhood cancer	en_US
dc.subject	Survivorship	en_US
dc.subject	Sleep	en_US
dc.subject	Fatigue	en_US
dc.subject	Acute Lymphoblastic Leukemia	en_US
dc.subject	ALL	en_US
dc.subject	Oncology	en_US
dc.subject	Pediatric	en_US
dc.subject	Psychosocial	en_US
dc.subject	Psychology	en_US
dc.subject.classification	Oncology	en_US
dc.subject.classification	Psychology--Clinical	en_US
dc.title	Sleep Disturbances and Fatigue in Survivors of Pediatric Acute Lymphoblastic Leukemia and their Siblings	en_US
dc.type	master thesis	en_US
thesis.degree.discipline	Psychology – Clinical	en_US
thesis.degree.grantor	University of Calgary	en_US
thesis.degree.name	Master of Science (MSc)	en_US
ucalgary.item.requestcopy	true	en_US