Characterizing the structure-function relationship of hand osteoarthritis using dynamic and high resolution CT imaging

Kuczynski, Michael Tadeusz

Characterizing the structure-function relationship of hand osteoarthritis using dynamic and high resolution CT imaging

dc.contributor.advisor	Manske, Sarah
dc.contributor.author	Kuczynski, Michael Tadeusz
dc.contributor.committeemember	Ronsky, Janet
dc.contributor.committeemember	Edwards, W. Brent
dc.contributor.committeemember	Schneider, Prism
dc.date	2024-05
dc.date.accessioned	2024-04-03T17:18:29Z
dc.date.available	2024-04-03T17:18:29Z
dc.date.issued	2024-03-27
dc.description.abstract	Osteoarthritis (OA) is the most common form of arthritis and affects the trapeziometacarpal (TMC) joint. While the etiology of OA is still not fully understood, it is a multifactorial disease with biomechanical factors associated in its development. The thumb is estimated to account for over 40% of the hand’s entire function, largely due to the TMC joint. A better understanding of structural and functional changes in TMC OA may improve our understanding of this degenerative joint disease. A recent advancement in computed tomography (CT) now allows for imaging moving joints in vivo. This technique, termed dynamic CT, provides a unique opportunity to quantify joint biomechanics in vivo. In this thesis, novel methodologies are presented that improve processing of dynamic and high-resolution peripheral quantitative CT (HR-pQCT) scans. These methodologies allow for semi-automated quantification of joint space and bone mineral density (BMD) in HR-pQCT scans and biomechanical outcomes from dynamic CT. The methodologies developed in this dissertation drastically reduce processing time for dynamic CT scans compared to previous literature. A cross-sectional study is presented that utilizes HR-pQCT to measure joint space (JS) changes in hand OA, the first of its kind. Maximum JS was significantly greater in OA than controls in the second and third distal interphalangeal (DIP2, DIP3) joints (DIP2: 2.07 mm vs. 1.88 mm; DIP3: 2.01 mm vs. 1.86 mm), and decreased hand function and increased hand disability were associated with increased radiographic TMC OA. A study was conducted to characterize normal TMC joint biomechanics in vivo using the presented methodologies. BMD was computed in anatomical quadrants of the TMC joint, and it was found that the radial-volar quadrant of the first metacarpal (426 mg HA/cm3) and ulnar-volar quadrant of the trapezium (373 mg HA/cm3) were significantly greater than other quadrants. When compared with proximity maps from dynamic CT, areas with high contact corresponded to quadrants with higher BMD. The results from this dissertation provide methodologies to analyze bone and joint changes with HR-pQCT and dynamic CT to better understand hand osteoarthritis.
dc.identifier.citation	Kuczynski, M. T. (2024). Characterizing the structure-function relationship of hand osteoarthritis using dynamic and high resolution CT imaging (Doctoral thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.
dc.identifier.uri	https://hdl.handle.net/1880/118346
dc.language.iso	en
dc.publisher.faculty	Graduate Studies
dc.publisher.institution	University of Calgary
dc.rights	University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subject	Hand
dc.subject	Osteoarthritis
dc.subject	Computed tomography
dc.subject	Dynamic CT
dc.subject	Joint biomechanics
dc.subject	Trapeziometacarpal
dc.subject.classification	Engineering--Biomedical
dc.title	Characterizing the structure-function relationship of hand osteoarthritis using dynamic and high resolution CT imaging
dc.type	doctoral thesis
thesis.degree.discipline	Engineering – Biomedical
thesis.degree.grantor	University of Calgary
thesis.degree.name	Doctor of Philosophy (PhD)
ucalgary.thesis.accesssetbystudent	I do not require a thesis withhold – my thesis will have open access and can be viewed and downloaded publicly as soon as possible.