The role of synovial progenitor cells in cartilage repair

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atmire.migration.oldid1906
dc.contributor.advisorKrawetz, Roman
dc.contributor.authorMak, Joyce
dc.date.accessioned2014-01-29T20:14:03Z
dc.date.available2014-03-15T07:00:19Z
dc.date.issued2014-01-29
dc.date.submitted2014en
dc.description.abstractIn this study, we have isolated a Sca-1 positive population of mouse synovial cells that contains progenitors capable of chondrogenesis. Intra-articular injection of Sca-1+-GFP+ synovial cells preserved proteoglycan content in the cartilage following cartilage injury but GFP expression could not be detected in the injury sites. Histological analysis suggests that in vivo mechanical stimulation of the injected cells due to joint loading results in the secretion of GAGs by the exogenous cells and thereby protects the joints from further degradation. Furthermore, progressive changes in cell morphology were observed in Sca-1+ synovial cells in response to injury, changing from a flatten, fibroblast-like appearance to a spherical and detached morphology 48 hours after injury. The presented study provides insight as to how endogenous synovial cells might act in response to injury as well as a mechanism by which the cells could protect the joint from degradation.en_US
dc.identifier.citationMak, J. (2014). The role of synovial progenitor cells in cartilage repair (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/28359en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/28359
dc.identifier.urihttp://hdl.handle.net/11023/1314
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectBiology--Cell
dc.subjectBiology--Molecular
dc.subject.classificationmesenchymal stem cellsen_US
dc.subject.classificationsynoviumen_US
dc.subject.classificationsynovial membraneen_US
dc.subject.classificationCartilageen_US
dc.subject.classificationrepairen_US
dc.subject.classificationmagnetic resonance imaging (MRI)en_US
dc.subject.classificationSca-1en_US
dc.subject.classificationstem cell trackingen_US
dc.subject.classificationin vivo imagingen_US
dc.titleThe role of synovial progenitor cells in cartilage repair
dc.typemaster thesis
thesis.degree.disciplineMedical Science
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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