Investigating the Relationship Between Cortical Grey Matter Hypoxia and Disability in Multiple Sclerosis

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dc.contributor.advisorDunn, Jeffrey F.
dc.contributor.advisorYong, Voon Wee
dc.contributor.authorEvans, Taelor
dc.contributor.committeememberKuipers, Hedwich Fardau
dc.contributor.committeememberPike, G. Bruce
dc.date.accessioned2020-06-26T17:01:53Z
dc.date.available2020-06-26T17:01:53Z
dc.date.issued2020-06-24
dc.description.abstractMultiple sclerosis (MS) is a progressive neurological disease characterized by inflammation and neurodegeneration. These pathological processes may be mediated by hypoxia, or reduced oxygenation. Thus, hypoxia may contribute to disability and therapeutic outcomes in MS. Near-infrared spectroscopy (NIRS) non-invasively measures absolute cortical oxygenation and can be used to quantify hypoxia. The goal of this thesis was to characterize the prevalence of grey matter (GM) hypoxia in people with MS (PwMS) using NIRS and to relate hypoxia to disability and treatment with disease-modifying therapies (DMTs). Results indicate that 30% of PwMS exhibit hypoxia, which is unexpectedly more common in patients treated with DMTs than untreated subjects. However, no clear association between hypoxia and physical or cognitive disability was observed. Therefore, GM hypoxia may reflect subclinical disease activity, although this needs to be explored. Overall, this thesis validates that NIRS bears potential for clinical use as an adjunctive imaging modality in MS.en_US
dc.identifier.citationEvans, T. (2020). Investigating the Relationship Between Cortical Grey Matter Hypoxia and Disability in Multiple Sclerosis (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/37952
dc.identifier.urihttp://hdl.handle.net/1880/112222
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.institutionUniversity of Calgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.en_US
dc.subjectmultiple sclerosisen_US
dc.subjecthypoxiaen_US
dc.subjectnear-infrared spectroscopyen_US
dc.subject.classificationNeuroscienceen_US
dc.subject.classificationPathologyen_US
dc.titleInvestigating the Relationship Between Cortical Grey Matter Hypoxia and Disability in Multiple Sclerosisen_US
dc.typemaster thesisen_US
thesis.degree.disciplineMedicine – Neuroscienceen_US
thesis.degree.grantorUniversity of Calgaryen_US
thesis.degree.nameMaster of Science (MSc)en_US
ucalgary.item.requestcopytrueen_US
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