Role of ING1b in Breast Cancer Promotion

Simple item page
atmire.migration.oldid5259
dc.contributor.advisorRiabowol, Karl
dc.contributor.authorBhunia, Pritha
dc.contributor.committeememberBeck, Paul
dc.contributor.committeememberDemetrick, Doug
dc.date.accessioned2017-02-02T19:55:19Z
dc.date.available2017-02-02T19:55:19Z
dc.date.issued2017
dc.date.submitted2017en
dc.description.abstractINGs or Inhibitor of Growth proteins act as type II tumor suppressors in epithelial cancers. The senescence associated secretory phenotype (SASP) is a phenomenon where senescent cells secrete a defined group of proteins including various proinflammatory cytokines. Cancer-associated fibroblasts (CAFs) are another component of the tumor microenvironment secreting various growth factors, proinflammatory cytokines and proteases. The proinflammatory cytokines secreted by CAFs and senescent cells as SASP cause chronic inflammation, which is one of the hallmarks of cancer. Although generally described as a tumor suppressor, our lab has recently reported that higher ING1 levels in the stroma correlate with poor survival outcome in breast cancer patients. To better understand this, we examined the effects of altering ING1b levels in fibroblasts. We find that ING1b increases the secretion of IL8, IL6, CXCL1 and CCL7 (also secreted by CAFs and in the SASP). This most likely occurs by ING1b activating NF-κB. Factors secreted by fibroblasts in response to ING1b also enhances the growth and migration capacity of several lines of breast cancer cells and also induce a cancer like phenotype of migration and growth in normal breast epithelial cells.en_US
dc.identifier.citationBhunia, P. (2017). Role of ING1b in Breast Cancer Promotion (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/27680en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/27680
dc.identifier.urihttp://hdl.handle.net/11023/3643
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectBiology--Molecular
dc.subjectOncology
dc.subject.otherING1
dc.subject.otherBreast Cancer
dc.subject.otherCancer associated fibroblasts
dc.subject.otherSenescence associated secretory phenotype
dc.subject.otherNFkB
dc.subject.otherCytokine
dc.titleRole of ING1b in Breast Cancer Promotion
dc.typemaster thesis
thesis.degree.disciplineBiochemistry and Molecular Biology
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
Files
Collections
Open Theses and Dissertations