The Effects of Azithromycin on Dextran Sulfate Sodium Colitis in Mice

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atmire.migration.oldid3249
dc.contributor.advisorMorck, Doug
dc.contributor.authorAnderson, Stefanie
dc.date.accessioned2015-05-20T19:30:59Z
dc.date.available2015-11-20T08:00:24Z
dc.date.issued2015-05-20
dc.date.submitted2015en
dc.description.abstractInflammatory bowel disease (IBD) is a heterogeneous group of chronic, relapsing inflammatory gastrointestinal diseases for which there is no cure. Many models of IBD exist, owing to the complex disease pathophysiology. Although immunosuppressants are mainstay treatments, antibiotics are frequently prescribed to decrease harmful bacteria, which can exacerbate immune responses. Azithromycin is a macrolide antibiotic with immunomodulatory functions that has been extensively studied in the airways, but few have examined its role in IBD. This project investigated several clinical, pathological, and immunomodulatory effects of azithromycin in a murine dextran sulfate sodium model of colitis. Azithromycin substantially mitigated clinical disease presentation, as assessed by animal behaviour, weight change, and gross pathology. However, these effects were not reflected on a microscopic, hematologic, or biochemical level, and no mechanism was found to explain them. The results highlight the importance of clinical assessment as a tool to determine therapeutic efficacy in colitis research.en_US
dc.identifier.citationAnderson, S. (2015). The Effects of Azithromycin on Dextran Sulfate Sodium Colitis in Mice (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/28098en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/28098
dc.identifier.urihttp://hdl.handle.net/11023/2261
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectAnimal Pathology
dc.subjectImmunology
dc.subjectMedicine and Surgery
dc.subject.classificationInflammatory Bowel Diseaseen_US
dc.subject.classificationAzithromycinen_US
dc.subject.classificationAntibioticen_US
dc.subject.classificationImmunologyen_US
dc.subject.classificationCrohn's diseaseen_US
dc.subject.classificationUlcerative Colitisen_US
dc.subject.classificationMacrolideen_US
dc.subject.classificationDextran Sulfate Sodiumen_US
dc.subject.classificationImmunomodulationen_US
dc.titleThe Effects of Azithromycin on Dextran Sulfate Sodium Colitis in Mice
dc.typemaster thesis
thesis.degree.disciplineBiological Sciences
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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