Modulation Of Fibroblast Function By Human Rhinovirus Infected Airway Epithelium

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atmire.migration.oldid3938
dc.contributor.advisorProud, David
dc.contributor.authorShelfoon, Christopher
dc.contributor.committeememberLeigh, Richard
dc.contributor.committeememberKelly, Margaret
dc.contributor.committeememberPatel, Kamala
dc.date.accessioned2015-12-23T18:05:50Z
dc.date.available2015-12-23T18:05:50Z
dc.date.issued2015-12-23
dc.date.submitted2015en
dc.description.abstractThickening of the lamina reticularis – a feature of airway remodeling in asthma – can be found in the airways of young children with wheeze. In association, wheezing illness due to human rhinovirus infection is an important risk factor for asthma development. We hypothesize that rhinovirus infection may be involved in the pathogenesis of lamina reticularis thickening and, by extension, airway remodeling. We show that upon infection with human rhinovirus the airway epithelium releases chemoattractants that are able to recruit human bronchial fibroblasts – the cell associated with lamina reticularis thickening. CXCL10 and CXCL8 were revealed as key players in this response, broadening their role in asthma pathogenesis. Additionally, fibroblast migration was experimentally abrogated using formoterol and other cAMP elevating agents. Taken together, the work in this thesis supports the hypothesis that rhinovirus infection is involved in the pathogenesis of airway remodeling.en_US
dc.identifier.citationShelfoon, C. (2015). Modulation Of Fibroblast Function By Human Rhinovirus Infected Airway Epithelium (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26975en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/26975
dc.identifier.urihttp://hdl.handle.net/11023/2711
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectBiology--Cell
dc.subject.classificationRhinovirusen_US
dc.subject.classificationFibroblasten_US
dc.subject.classificationAsthmaen_US
dc.subject.classificationRemodelingen_US
dc.titleModulation Of Fibroblast Function By Human Rhinovirus Infected Airway Epithelium
dc.typemaster thesis
thesis.degree.disciplineCardiovascular & Respiratory Sciences
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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