A General Strategy for the Preparation of Thalidomide-Conjugate Linkers

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dc.contributor.authorPapatzimas, James
dc.contributor.authorGorobets, Evgueni
dc.contributor.authorBrownsey, Duncan
dc.contributor.authorMaity, Ranjan
dc.contributor.authorBahlis, Nizar
dc.contributor.authorDerksen, Darren
dc.date.accessioned2021-09-01T22:42:00Z
dc.date.available2021-09-01T22:42:00Z
dc.date.issued2017-01
dc.description.abstractThe synthesis of small-molecule linkers for installation of thalidomide-based conjugates is described. Linker properties have been recognized as vital to conjugate success in drug discovery and delivery systems. These small-molecule tethers act as linkages between molecules, can also aid in cell permeability, and act as solubilizing agents. This work shows our progress in synthesizing conjugates with a variety of linker characteristics. The adaptability and manipulation of these and other linkers holds potential in improving synthetic control of chemical connectivities toward therapeutic development.en_US
dc.description.grantingagencyNatural Sciences and Engineering Research Council (NSERC)en_US
dc.identifier.citationPapatzimas, J. W., Gorobets, E., Brownsey, D. K., Maity, R., Bahlis, N. J., & Derksen, D. J. (2017). A general strategy for the preparation of thalidomide-conjugate linkers. Synlett, 28(20), 2881-2885.en_US
dc.identifier.doihttp://dx.doi.org/10.1055/s-0036-1588539en_US
dc.identifier.urihttp://hdl.handle.net/1880/113800
dc.identifier.urihttps://doi.org/10.11575/PRISM/46134
dc.language.isoengen_US
dc.publisher.departmentChemistryen_US
dc.publisher.facultyScienceen_US
dc.publisher.hasversionacceptedVersionen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.rightsUnless otherwise indicated, this material is protected by copyright and has been made available with authorization from the copyright owner. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.en_US
dc.subjectPROTACen_US
dc.subjectthalidomideen_US
dc.subjectconjugatesen_US
dc.subjectlinkeren_US
dc.subjectpentafluoroĀ­phenyl esteren_US
dc.titleA General Strategy for the Preparation of Thalidomide-Conjugate Linkersen_US
dc.typejournal articleen_US
ucalgary.item.requestcopytrueen_US
ucalgary.scholar.levelFacultyen_US
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