Impact of an Early Life Immune Challenge on Outcomes in a Rat Model of Pediatric Mild Traumatic Brain Injury

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atmire.migration.oldid4435
dc.contributor.advisorEsser, Michael
dc.contributor.authorCandy, Sydney Alexandra
dc.contributor.committeememberPittman, Quentin
dc.contributor.committeememberMychasiuk, Richelle
dc.date.accessioned2016-05-18T18:43:59Z
dc.date.available2016-05-18T18:43:59Z
dc.date.issued2016
dc.date.submitted2016en
dc.description.abstractThe focus of this thesis was to determine if neonatal exposure to lipopolysaccharide (LPS) on postnatal day (P) 10 would affect the behavioural and molecular outcomes after mild traumatic brain injury (mTBI) on P30. It appears that female LPS + mTBI rats show alterations in measures of anxiety, working memory and depressive-like behaviour - different from those not previously exposed to LPS. In addition to behavioural changes, the mRNA expression profiles of LPS + mTBI rats showed a differential cytokine response at P45 in comparison to rats that received LPS, mTBI, or saline injury controls (SAL + mTBI). Cytokine mRNA levels were followed up by analyzing two microglia/macrophage phenotype markers; the markers also showed an altered profile for LPS + mTBI animals. The findings of the work highlight the importance of sex differences and suggest that an early life immune challenge could confer selective susceptibility to outcomes after mTBI.en_US
dc.identifier.citationCandy, S. A. (2016). Impact of an Early Life Immune Challenge on Outcomes in a Rat Model of Pediatric Mild Traumatic Brain Injury (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26455en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/26455
dc.identifier.urihttp://hdl.handle.net/11023/3023
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectNeuroscience
dc.subject.classificationInflammationen_US
dc.subject.classificationConcussionen_US
dc.titleImpact of an Early Life Immune Challenge on Outcomes in a Rat Model of Pediatric Mild Traumatic Brain Injury
dc.typemaster thesis
thesis.degree.disciplineNeuroscience
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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