The SORT1 Protective Allele is Associated with Attenuated Postprandial Lipaemia in Young Adults
| atmire.migration.oldid | 2177 | |
| dc.contributor.advisor | Hittel, Dustin | |
| dc.contributor.author | Connors, Kimberly | |
| dc.date.accessioned | 2014-05-21T17:38:47Z | |
| dc.date.available | 2014-11-17T08:00:25Z | |
| dc.date.issued | 2014-05-21 | |
| dc.date.submitted | 2014 | en |
| dc.description.abstract | Elevated levels of lipids and lipoproteins have strong genetic determinants, and are key risk factors for cardiovascular disease. Study aims were to determine if young adults, when stratified by genotype at the rs646776 variant of the 1p13 locus, displayed differential postprandial responses to an oral fat tolerance test. Participants received a high fat mixed meal following an overnight fast and a fat-exclusion meal at 8 h postprandially. Blood samples were obtained at t=0, 2, 4, 6, 8 and 24 h for lipoprotein analyses via nuclear magnetic resonance profiling. Carriers of the minor, protective allele (TC/CC) displayed lower concentrations of fasting and postprandial very-low density lipoproteins and chylomicrons, in addition to triglyceride content, compared to major, risk allele homozygotes (TT). We report a novel association between the SORT1 1p13 locus and postprandial lipaemia. These results provide evidence of decreased exposure to atherogenic particles in carriers of the minor SORT1 allele, suggesting relative protection against cardiovascular disease compared to TT homozygotes. | en_US |
| dc.identifier.citation | Connors, K. (2014). The SORT1 Protective Allele is Associated with Attenuated Postprandial Lipaemia in Young Adults (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/28385 | en_US |
| dc.identifier.doi | http://dx.doi.org/10.11575/PRISM/28385 | |
| dc.identifier.uri | http://hdl.handle.net/11023/1535 | |
| dc.language.iso | eng | |
| dc.publisher.faculty | Graduate Studies | |
| dc.publisher.faculty | Kinesiology | |
| dc.publisher.institution | University of Calgary | en |
| dc.publisher.place | Calgary | en |
| dc.rights | University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission. | |
| dc.subject | Genetics | |
| dc.subject | Nutrition | |
| dc.subject.classification | Postprandial Lipaemia | en_US |
| dc.subject.classification | Genetics | en_US |
| dc.subject.classification | Atherosclerosis | en_US |
| dc.subject.classification | Young Adults | en_US |
| dc.title | The SORT1 Protective Allele is Associated with Attenuated Postprandial Lipaemia in Young Adults | |
| dc.type | master thesis | |
| thesis.degree.grantor | University of Calgary | |
| thesis.degree.name | Master of Science (MSc) | |
| ucalgary.item.requestcopy | true |