The role of L tyrosine in oxazolone induced skin inflammation

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dc.contributor.authorTso, Marcus
dc.contributor.authorLin, Yujia
dc.contributor.authorLiao, Shan
dc.date.accessioned2019-11-06T19:56:41Z
dc.date.available2019-11-06T19:56:41Z
dc.date.issued2017-11-30
dc.description.abstractPerinodal adipose tissues (PAT) are adipose tissue that directly surrounds lymph nodes (LN). Under local immune stimulation, PAT had been shown to breakdown fat and supply fatty acids essential to proliferating lymphoid cells. However, knowledge of the interaction between PAT and LN remains incomplete. Metabolomic analysis identified 458 common metabolites between the LN and PAT. Within these common metabolites, L-tyrosine was found to be significantly reduced in LN, PAT, and plasma during oxazolone (OX) skin sensitization induced inflammation. Literature show that immune cells can increase uptake of amino acids and alter their metabolic profiles to respond to immune stimulation. This study investigates the role of L-tyrosine in OX-induced skin inflammation. Tyrosine hydroxylase (TH), one of the major enzymes that metabolizes L-tyrosine, was found to be expressed in the lymph nodes of normal mice. Immunofluorescence imaging showed that TH was expressed by cells mostly in the T cell zone. TH expression pattern and co-staining with various cell markers suggested that TH was expressed by neurons in the lymph node. The TH expressing neurons appears to wiring CD4+ cells. Further experiments are needed to characterize TH-expressing cells, and to determine changes in TH expression between control and OX-inflamed LNs.en_US
dc.identifier.citationTso, M., Lin, Y., & Liao, S. (2017). "The role of L tyrosine in oxazolone induced skin inflammation". Conference poster. 12th Annual Students' Union Undergraduate Research Symposium, November 30, 2017. University of Calgary, Calgary, AB.en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/37236
dc.identifier.urihttp://hdl.handle.net/1880/111204
dc.language.isoengen_US
dc.publisher.departmentMicrobiology, Immunology & Infectious Diseasesen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.subjectImmunologyen_US
dc.subjectLymphaticsen_US
dc.subjectLymph nodesen_US
dc.subjectPerinodal adipose tissueen_US
dc.subjectInflammationen_US
dc.titleThe role of L tyrosine in oxazolone induced skin inflammationen_US
dc.typeconference posteren_US
ucalgary.item.requestcopytrueen_US
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