Influence of dietary antioxidant and oxidant intake on leukocyte telomere length

Simple item page
atmire.migration.oldid5815
dc.contributor.advisorFriedenreich, Christine Marthe
dc.contributor.advisorBrenner, Darren
dc.contributor.authorMickle, Alexis Tory
dc.contributor.committeememberBeattie, Tara
dc.contributor.committeememberWilliamson, Tyler
dc.date.accessioned2017-07-25T15:21:24Z
dc.date.available2017-07-25T15:21:24Z
dc.date.issued2017
dc.date.submitted2017en
dc.description.abstractBackground: Telomeric DNA is highly susceptible to oxidative damage, and dietary habits may impact telomere attrition rates through the mediation of oxidative stress and chronic inflammation. Objectives: To examine the association between both the Dietary Inflammatory Index 2010 (DII) and the Alternative Healthy Eating Index 2010 (AHEI) with relative Leukocyte Telomere Length. Design: We conducted a cross-sectional analysis using baseline data from 301 healthy, inactive post-menopausal women. Diet quality was estimated using DII and AHEI scores derived from food frequency questionnaire data. LTL was measured using qPCR. Associations were examined using multivariable adjusted linear regression. Results: No statistically significant associations were detected between AHEI (p=0.20) or DII (p=0.91) and LTL in multivariable adjusted models. Conclusions: AHEI or DII scores were not related to LTL in this population. Future research is warranted to enhance understanding regarding the molecular processes involved in the relations between diet, telomere length and chronic disease risk.en_US
dc.identifier.citationMickle, A. T. (2017). Influence of dietary antioxidant and oxidant intake on leukocyte telomere length (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26514en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/26514
dc.identifier.urihttp://hdl.handle.net/11023/3983
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectEpidemiology
dc.subject.othertelomere
dc.subject.otherdietary inflammatory index
dc.subject.otheralternative healthy eating index
dc.subject.otheroxidant
dc.subject.otherantioxidant
dc.subject.otherreactive oxygen species
dc.subject.otherchronic inflammation
dc.subject.otherOxidative stress
dc.subject.otheranthocyanidin
dc.subject.otherflavonoid
dc.subject.othergenetic stability
dc.subject.othergenetic integrity
dc.subject.otherdiet
dc.titleInfluence of dietary antioxidant and oxidant intake on leukocyte telomere length
dc.typemaster thesis
thesis.degree.disciplineCommunity Health Sciences
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
Files
Collections
Open Theses and Dissertations