Sensorimotor behaviour following incomplete cervical spinal cord injury in the rat

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dc.contributor.authorWebb, Aubrey Aeng
dc.contributor.authorMuir, Gillian Deng
dc.date.accessioned2008-08-21T21:49:29Z
dc.date.available2008-08-21T21:49:29Z
dc.date.issued2005-12
dc.description.abstractRats are one of the most commonly used species for spinal cord injury research. Since the advent of the Basso, Beattie, Bresnahan (BBB) locomotor rating scale, the majority of spinal cord injury research relies upon evaluating locomotor behaviour in thoracic spinal cord injury rat models. Slightly more than 50% of all traumatic spinal cord injuries in humans, however, occur at the level of the cervical spinal cord. Further, therapies aimed at thoracic spinal cord injuries may not be directly transferable to cervical spinal cord injuries. This could be due to (1) differences in distance between the cell bodies of injured axons and the injury site and (2) because some behaviours (e.g. stepping movements) used to evaluate the therapeutic potential of a given treatment are governed primarily by intraspinal neuronal circuitry while other behaviours (e.g. skilled reaching) require more sophisticated conscious integration of the sensorimotor system. Consequently, there is a need to develop and use experimental cervical spinal cord injury models and understand the behavioural characteristics of such models. The present review highlights the sensorimotor abilities of cervical spinal cord-injured rats, including both forelimb, hind limb, and whole body behaviours. We also provide insight into the neuroanatomic substrates important for performing a given behaviour, information which may prove essential in the development of site-directed therapeutic strategies.eng
dc.description.refereedYeseng
dc.identifier.citationBehavioural Brain Research 2005 165: 147-159eng
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/35628
dc.identifier.issn0166-4328
dc.identifier.urihttp://hdl.handle.net/1880/46769
dc.language.isoengeng
dc.publisherElseviereng
dc.publisher.corporateUniversity of Calgaryeng
dc.publisher.facultyVeterinary Medicineeng
dc.publisher.urlhttp://www.sciencedirect.comeng
dc.subjectLocomotioneng
dc.subjectSpinal cord injuryeng
dc.subject.otherReachingeng
dc.titleSensorimotor behaviour following incomplete cervical spinal cord injury in the rateng
dc.typejournal article
thesis.degree.disciplineComparative Biology and Experimental Medicineeng
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