Mapping developmental motor plasticity in children with perinatal stroke using functional magnetic resonance imaging
Abstract
Perinatal stroke results in lifelong unilateral motor impairment. Periventricular venous infarct (PVI) is a subcortical injury sustained in utero whereas arterial ischemic stroke (AIS) occurs near term birth and often damages the primary motor cortex (M1). Both disease-states result in the maladaptive emergence of aberrant ipsilateral (M1’) connections. Task-based functional magnetic resonance imaging defined patterns of motor cortex activity during unilateral tapping of the paretic and non-paretic hand. Peak bilateral coordinates of M1 and M1’ were compared to controls. AIS cases displayed the greatest extent of M1 displacement in the lesioned hemisphere, but M1 displacement in PVI cases approximated controls. For stroke cases with bilateral control of their paretic hand, M1’ responses in the intact hemisphere were displaced from the canonical hand knob. We conclude that extensive motor reorganization occurs bilaterally following perinatal stroke. Targeting individualized M1 and M1’ displacements may facilitate opportunities for precision medicine in pediatric neurorehabilitation.
Description
Keywords
Neuroscience
Citation
Baker, K. (2017). Mapping developmental motor plasticity in children with perinatal stroke using functional magnetic resonance imaging (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26829