Measurement of the Cerebellar Vermis in Bipolar Disorder and the Effect of Lithium Treatment

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atmire.migration.oldid2098
dc.contributor.advisorMacMaster, Frank
dc.contributor.advisorMacQueen, Glenda
dc.contributor.authorMahnke, Devin
dc.date.accessioned2014-05-01T20:19:08Z
dc.date.available2014-06-16T07:00:38Z
dc.date.issued2014-05-01
dc.date.submitted2014en
dc.description.abstractPrevious studies have suggested that the cerebellar vermis may be smaller in individuals with bipolar disorder, but these findings are inconsistent and have not considered the potential impact of medication. To address these knowledge gaps, the cerebellar vermis was measured using structural magnetic resonance imaging in both an adolescent and an adult sample. Analysis of variance was performed on the cross-sectional area of the three vermal lobes and on the total area. There were no significant differences between adolescent or adult bipolar subjects compared to healthy controls in any region, regardless of lithium treatment. In addition, a medication-naïve subset of the adult population underwent a two-year course of lithium treatment and was then reassessed. No changes in vermis area were found within subjects across the treatment. These results, combined with literature meta-analysis, indicate no clear effect of either bipolar disorder, or lithium treatment, on the size of the cerebellar vermis.en_US
dc.identifier.citationMahnke, D. (2014). Measurement of the Cerebellar Vermis in Bipolar Disorder and the Effect of Lithium Treatment (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26850en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/26850
dc.identifier.urihttp://hdl.handle.net/11023/1466
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectNeuroscience
dc.subjectMental Health
dc.subject.classificationbipolar disorderen_US
dc.subject.classificationcerebellar vermisen_US
dc.subject.classificationMRIen_US
dc.subject.classificationlithiumen_US
dc.titleMeasurement of the Cerebellar Vermis in Bipolar Disorder and the Effect of Lithium Treatment
dc.typemaster thesis
thesis.degree.disciplineNeuroscience
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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