Role of arterial PO2 and PCO2 in the regulation of brachial blood flow in humans

Simple item page
dc.contributor.advisorHepple, Russell
dc.contributor.authorAshmead, Jon C.
dc.date.accessioned2005-08-16T17:06:30Z
dc.date.available2005-08-16T17:06:30Z
dc.date.issued2004
dc.descriptionBibliography: p. 128-152en
dc.descriptionSome pages are in colour.en
dc.description.abstractThis study examined the role of arterial PO2 (PaO2) and PCO2 (PaCO2) in the regulation of brachial blood flow (BBF) in humans. Nine healthy male subjects participated in five 60-min experimental conditions: isocapnic hypoxia, isocapnic hyperoxia, euoxic hypocapnia, euoxic hypercapnia, and euoxia isocapnia (control). Dynamic end-tidal forcing was used to control end-tidal (i.e., arterial) PO2 and PCO2. Doppler ultrasound was used to measure BBF. Hypoxia elicited a sustained increase in BBF (25 ± 14%; P<0.05), whereas hyperoxia caused a sustained decrease in BBF (15 ± 8%; PO.05). Hypocapnia elicited a biphasic response, where BBF transiently increased (31 ± 17%; PO.05) after 2 min and abruptly declined (25 ± 14% below baseline) thereafter. During hypercapnia BBF initially increased (14 ± 10%; P<0.05), but returned to baseline values after 20 min. The present study provides direct evidence that alterations in PaO2 and PaCO2 have dynamic effects on blood flow regulation through the brachial artery. brachial blood flow, hypoxia, hyperoxia, hypocapnia, hypercapnia, euoxia, isocapniaen
dc.format.extentxvii, 202 leaves : ill. ; 30 cm.en
dc.identifier.citationAshmead, J. C. (2004). Role of arterial PO2 and PCO2 in the regulation of brachial blood flow in humans (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/20823en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/20823
dc.identifier.isbn0612976270en
dc.identifier.lccAC1 .T484 2004 A77en
dc.identifier.urihttp://hdl.handle.net/1880/41672
dc.language.isoeng
dc.publisher.facultyKinesiology
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.titleRole of arterial PO2 and PCO2 in the regulation of brachial blood flow in humans
dc.typemaster thesis
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
ucalgary.thesis.accessionTheses Collection 58.002:Box 1487 520492004
ucalgary.thesis.notesUARCen
ucalgary.thesis.uarcreleaseyen
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
2004_Ashmead.pdf
Size:
26.22 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Legacy Theses