Novel role of integrin ligands in neuromodulation

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dc.contributor.advisorBulloch, Andrew G. M.
dc.contributor.advisorWildering, Willem C.
dc.contributor.authorDiep, Chi Que
dc.date.accessioned2005-08-16T16:55:41Z
dc.date.available2005-08-16T16:55:41Z
dc.date.issued2004
dc.descriptionBibliography: p. 95-107en
dc.description.abstractIntegrins, a family of cell adhesion receptors, and their ligands, the extracellular matrix proteins, have been implicated as neuromodulators in the adult CNS. Previous studies from our laboratory on neurons isolated from the CNS of the gastropod snail Lymnaea stagnalis show that integrin peptides increase HVA Ca2+ concentrations and other active intrinsic membrane properties. The current study extends this line of investigation to the intact CNS. Extracellular electrophysiological recording from the trunk of one of the nerves (right internal parietal or RIP nerve) originating from the Lymnaea CNS shows that integrin peptide with the consensus integrin binding motif RDG increases the electrical discharge of some projecting neurons. Further investigations, involving the intracellular recording from 2 synaptic partners that have axonal projections in the RIP nerve, provide evidence that in the Lymnaea CNS integrins play a role in synaptic modulation since they modulate the kinetics of the postsynaptic potentials through synaptic remodeling.en
dc.format.extentxi, 107 leaves : ill. ; 30 cm.en
dc.identifier.citationDiep, C. Q. (2004). Novel role of integrin ligands in neuromodulation (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/20237en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/20237
dc.identifier.isbn0494056843en
dc.identifier.lccAC1 .T484 2004 D535en
dc.identifier.urihttp://hdl.handle.net/1880/41457
dc.language.isoeng
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.titleNovel role of integrin ligands in neuromodulation
dc.typemaster thesis
thesis.degree.disciplineNeuroscience
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
ucalgary.thesis.accessionTheses Collection 58.002:Box 1497 520492014
ucalgary.thesis.notesUARCen
ucalgary.thesis.uarcreleaseyen
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