The Involvement of the Intergeniculate Leaflet in the Potentiation of Photic Phase Shifts by the 5-HT1A Mixed Agonist/Antagonist BMY 7378

Simple item page
atmire.migration.oldid1419
dc.contributor.advisorAntle, Michael
dc.contributor.authorJeffers, Ryan
dc.date.accessioned2013-09-23T18:44:21Z
dc.date.available2013-11-12T08:00:10Z
dc.date.issued2013-09-23
dc.date.submitted2013en
dc.description.abstractThe suprachiasmatic nucleus (SCN) is the master circadian pacemaker. Photic stimuli conveyed by fibers innervating the SCN can synchronize the master clock with the environment. The serotonin (5-HT) 1A mixed agonist/antagonist BMY 7378 can enhance the magnitude of these changes, which could help realign the circadian rhythms of individuals whose rhythms have become desynchronized. Direct administration of BMY 7378 to the SCN is not sufficient to enhance phase shift to light. The intergeniculate leaflet (IGL) like the SCN receives both direct retinal input and serotonergic innervation; therefore BMY 7378 may be exerting its influence through the IGL. Radio frequency lesion of the IGL and neurotoxic lesion of the 5-HT fibers innervating the IGL both result in phase shift to light which are not significantly larger than controls, indicating that both are necessary for BMY 7378 to potentiate photic phase shifts.en_US
dc.identifier.citationJeffers, R. (2013). The Involvement of the Intergeniculate Leaflet in the Potentiation of Photic Phase Shifts by the 5-HT1A Mixed Agonist/Antagonist BMY 7378 (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/28225en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/28225
dc.identifier.urihttp://hdl.handle.net/11023/991
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectPsychobiology
dc.subject.classificationCircadain Rhythms, Serotonin, BMY 7378, Intergeniculate Leafleten_US
dc.titleThe Involvement of the Intergeniculate Leaflet in the Potentiation of Photic Phase Shifts by the 5-HT1A Mixed Agonist/Antagonist BMY 7378
dc.typemaster thesis
thesis.degree.disciplinePsychology
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ucalgary_2013_jeffers_ryan.pdf
Size:
1.25 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
2.65 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Open Theses and Dissertations