Activation of Epiplexus Cells by ATP

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atmire.migration.oldid680
dc.contributor.advisorThompson, Roger John
dc.contributor.authorMaslieieva, Valentyna
dc.date.accessioned2013-01-25T22:50:37Z
dc.date.available2013-06-15T07:01:47Z
dc.date.issued2013-01-25
dc.date.submitted2013en
dc.description.abstractEpiplexus cells represent a population of innate immune cells on the surface of the choroid plexus (CP) in the brain ventricles. I hypothesized that the epiplexus cells are involved in immune responses of the CP via sensitivity to immune mediators such as ATP. A novel technique for the isolation of live and intact rat CP was developed that allowed, for the first time, observation and quantification of physiological responses of epiplexus cells in situ. Bath application of ATP, as well as ADP or UTP, activated movement (chemokinesis) of epiplexus cells. This was not dependent upon P2X7 and P2X4 receptors, but may involve epiplexus cell P2X1, P2X5, and / or P2Y13 and P2Y2 receptors and epithelial cell pannexin-1. Therefore, epiplexus cells respond to the immune mediator, ATP, and may receive signals directly from the epithelium on which they reside to mediate localized immune responses in the ventricle.en_US
dc.identifier.citationMaslieieva, V. (2013). Activation of Epiplexus Cells by ATP (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/24689en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/24689
dc.identifier.urihttp://hdl.handle.net/11023/504
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectNeuroscience
dc.subjectPhysiology
dc.subjectImmunology
dc.subject.classificationepiplexusen_US
dc.subject.classificationkolmeren_US
dc.subject.classificationmacrophageen_US
dc.subject.classificationchoroid plexusen_US
dc.subject.classificationATPen_US
dc.subject.classificationUTPen_US
dc.subject.classificationpurinergicen_US
dc.subject.classificationreceptoren_US
dc.subject.classificationchemokinesisen_US
dc.subject.classificationchemotaxisen_US
dc.subject.classificationMigrationen_US
dc.subject.classificationActivationen_US
dc.subject.classificationPannexin-1en_US
dc.subject.classificationraten_US
dc.subject.classificationventricleen_US
dc.subject.classificationimmuneen_US
dc.subject.classificationP2Xen_US
dc.subject.classificationP2Yen_US
dc.subject.classificationInflammationen_US
dc.subject.classificationADPen_US
dc.subject.classificationadenosineen_US
dc.subject.classificationBCSFBen_US
dc.subject.classificationCSFen_US
dc.subject.classificationinnateen_US
dc.subject.classificationCNSen_US
dc.subject.classificationbrainen_US
dc.subject.classificationIB4en_US
dc.titleActivation of Epiplexus Cells by ATP
dc.typemaster thesis
thesis.degree.disciplineNeuroscience
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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