Lung Proteomics of Mice Infected with Influenza

Subha, Maneesha

Lung Proteomics of Mice Infected with Influenza

dc.contributor.advisor	Jenne, Craig
dc.contributor.author	Subha, Maneesha
dc.contributor.committeemember	Dufour, Antoine
dc.contributor.committeemember	Deniset, Justin
dc.date	2025-05
dc.date.accessioned	2025-01-02T22:58:47Z
dc.date.available	2025-01-02T22:58:47Z
dc.date.issued	2025-01-02
dc.description.abstract	Influenza A virus (IAV) infection causes an inflammatory reaction and activation of coagulation, which is often the basis for destruction of lung tissue. This study examines the changes to the of lungs from IAV-infected mice and assesses the effectiveness of Argatroban, a thrombin inhibitor, when given early in the infection. Pro-inflammatory and cell adhesion proteins were significantly upregulated in lung tissue on the first day after infection. As disease progressed, proteins related to coagulation, immunological signaling, and oxidative stress were more highly expressed in infected lungs. Argatroban treatment notably shifted the proteomic response on Day 1 and Day 5 post- infection, pointing to the ability of argatroban to control oxidative and inflammatory reactions during IAV infection, which may have consequences for maintaining lung function and reducing tissue damage brought on by the virus.
dc.identifier.citation	Subha, M. (2025). Lung proteomics of mice infected with influenza (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.
dc.identifier.uri	https://hdl.handle.net/1880/120343
dc.language.iso	en
dc.publisher.faculty	Graduate Studies
dc.publisher.institution	University of Calgary
dc.rights	University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subject	Influenza
dc.subject	Proteomics
dc.subject.classification	Immunology
dc.title	Lung Proteomics of Mice Infected with Influenza
dc.type	master thesis
thesis.degree.discipline	Medicine – Biochemistry and Molecular Biology
thesis.degree.grantor	University of Calgary
thesis.degree.name	Master of Science (MSc)
ucalgary.thesis.accesssetbystudent	I do not require a thesis withhold – my thesis will have open access and can be viewed and downloaded publicly as soon as possible.