Unilateral dorsal solumn and rubrospinal tract injuries affect overground locomotion in the unrestrained rat

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dc.contributor.authorWebb, Aubrey Aeng
dc.contributor.authorMuir, Gillian Deng
dc.date.accessioned2008-08-21T21:18:14Z
dc.date.available2008-08-21T21:18:14Z
dc.date.issued2003-07
dc.description.abstractThe purpose of this study was to determine the importance of the rubrospinal pathway and the ascending components of the dorsal column for overground locomotion in adult, unrestrained rats. The dorsal column (excluding the corticospinal tract), the rubrospinal tract or both were damaged unilaterally in rats at the level of the upper cervical spinal cord. Behavioural analysis consisted of skilled locomotion (an evaluation of footslips during ladder walking), a paw usage task and the assessment of ground reaction forces during unrestrained locomotion. All lesioned animals used the forepaw ipsilateral to the lesions less while rearing. Animals with dorsal column injuries used the forelimb contralateral to the spinal injury significantly more while rearing compared with uninjured animals. All lesioned animals produced more footfalls while crossing the ladder compared with uninjured animals. All injuries, regardless of the pathway affected, resulted in significant alterations in body weight support and reduced braking forces from the forelimb ipsilateral to the injury during overground locomotion. Animals typically bore less weight on the hindlimb ipsilateral to the lesion compared with the hindlimb contralateral to the spinal injury. Taken together with previously published work, our data indicate that the rubrospinal and dorsal column pathways are important for forelimb support while rearing and for skilled locomotion. Additionally, the ascending dorsal column pathways and the rubrospinal tract play a role during flat surface overground locomotion and combined damage to these pathways does not alter the acquired gait.eng
dc.description.notesThe definitive version is available at www3.interscience.wiley.com
dc.description.refereedYeseng
dc.identifier.citationEuropean Journal of Neuroscienceeng
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/35629
dc.identifier.issn0953-816X z
dc.identifier.issn1460-9568
dc.identifier.urihttp://hdl.handle.net/1880/46766
dc.language.isoengeng
dc.publisherBlackwelleng
dc.publisher.corporateUniversity of Calgaryeng
dc.publisher.facultyVeterinary Medicineeng
dc.publisher.urlhttp://www.blackwellpublishing.comeng
dc.subjectbehavioureng
dc.subjectinjury, spinaleng
dc.subject.otherdorsolateral funculuseng
dc.subject.otherground reaction forceseng
dc.titleUnilateral dorsal solumn and rubrospinal tract injuries affect overground locomotion in the unrestrained rateng
dc.typejournal article
thesis.degree.disciplineComparative Biology and Experimental Medicineeng
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