The Effect of Cigarette Smoking as a Modifiable Risk Factor for Secondary Progression in Multiple Sclerosis

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dc.contributor.advisorKoch, Marcus W.
dc.contributor.advisorPatten, Scott B.
dc.contributor.authorJavizian, Omid
dc.contributor.committeememberKorngut, Lawrence
dc.date2020-11
dc.date.accessioned2020-07-31T18:06:58Z
dc.date.available2020-07-31T18:06:58Z
dc.date.issued2020-07-28
dc.description.abstractObjective: To investigate the influence of cigarette smoking on disease progression and disability accumulation in multiple sclerosis (MS). Methods: Kaplan-Meier analyses and Cox proportional hazard modelling were used to evaluate the influence of cigarette smoking on the time to- and age at onset of secondary progressive MS (SPMS), and on time from disease onset to Expanded Disability Status Scale (EDSS) 4.0 and 6.0 as well as the time between EDSS 4.0 to 6.0 in 763 patients with SPMS. Results: No significant associations between cigarette smoking and disease progression as measured by time to- and age at onset of SPMS, or disability accumulation, as measured by time to and age at EDSS 4.0 and 6.0 were identified. Conclusion: Our investigation of a large and well-characterized population-based SPMS cohort suggests that cigarette smoking does not influence disease progression or disability accumulation in SPMS patients.en_US
dc.identifier.citationJavizian, O. (2020). The Effect of Cigarette Smoking as a Modifiable Risk Factor for Secondary Progression in Multiple Sclerosis (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/38054
dc.identifier.urihttp://hdl.handle.net/1880/112351
dc.language.isoengen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.institutionUniversity of Calgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.en_US
dc.subjectMultiple Sclerosisen_US
dc.subjectSecondary Progressive Multiple Sclerosisen_US
dc.subjectCigarette Smokingen_US
dc.subjectDisease Progressionen_US
dc.subjectDisability Accumulationen_US
dc.subject.classificationNeuroscienceen_US
dc.subject.classificationEpidemiologyen_US
dc.titleThe Effect of Cigarette Smoking as a Modifiable Risk Factor for Secondary Progression in Multiple Sclerosisen_US
dc.typemaster thesisen_US
thesis.degree.disciplineMedicine – Neuroscienceen_US
thesis.degree.grantorUniversity of Calgaryen_US
thesis.degree.nameMaster of Science (MSc)en_US
ucalgary.item.requestcopyfalseen_US
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