Association between glycemic load and cognitive function in community-dwelling older adults: results from the Brain in Motion study

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atmire.migration.oldid5736
dc.contributor.advisorPoulin, Marc
dc.contributor.authorGarber, Anna
dc.contributor.committeememberFriedenreich, Christine
dc.contributor.committeememberCsizmadi, Ilona
dc.contributor.committeememberLongman, Richard S.
dc.contributor.committeememberSajobi, Tolulope
dc.contributor.committeememberShearer, Jane
dc.date.accessioned2017-07-05T17:59:11Z
dc.date.available2017-07-05T17:59:11Z
dc.date.issued2017
dc.date.submitted2017en
dc.description.abstractBackground: Impaired glucose tolerance is a risk factor for non-age-related cognitive decline and is also associated with measures of physical activity (PA) and cardiorespiratory fitness (CRF). A low glycemic load (GL) diet can aid in the management of blood glucose levels, but little is known about its effect on cognition with poor glucoregulation. Objective: The aim of this thesis was to assess the relation between GL and cognitive function by glucoregulation, and possible mediatory effects by CRF and PA, in older adults. Design: A cross-sectional analysis of 194 cognitively healthy adults aged ≥55 years (mean=65.7, SD=6.1) was conducted. GL was assessed using a quantitative food frequency questionnaire, and glucoregulation was characterized on the HOMA-IR index. Subjects also completed a cognitive assessment, CRF testing, a validated self-reported PA questionnaire, and a blood draw. Multiple linear regression models adjusted for significant covariates were used to evaluate the relation between GL and cognition, and mediation analysis was used to assess potential mediatory effects by CRF and PA. Results: GL was inversely associated with global cognition (β=-0.014; 95% CI -0.024, -0.0036) and figural memory (β =-0.035; 95% CI -0.052, -0.018) in subjects with poor glucoregulation. Neither CRF nor PA mediated these relations. In subjects with good glucoregulation, no association was found between GL and cognitive function (p>0.05). Conclusions: A low GL diet is associated with better cognitive function in older adults with poor glucoregulation. This study provides supportive evidence for the role of GL in maintaining better cognitive function during the aging process.en_US
dc.identifier.citationGarber, A. (2017). Association between glycemic load and cognitive function in community-dwelling older adults: results from the Brain in Motion study (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25033en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/25033
dc.identifier.urihttp://hdl.handle.net/11023/3928
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectEpidemiology
dc.subjectMental Health
dc.subjectNutrition
dc.subject.otherglycemic load
dc.subject.othercognitive function
dc.subject.otherglucoregulation
dc.subject.otherimpaired glucose tolerance
dc.subject.otheraging
dc.subject.otherCognitive aging
dc.subject.othermiddle-aged
dc.subject.otheraged
dc.subject.othercross-sectional study
dc.titleAssociation between glycemic load and cognitive function in community-dwelling older adults: results from the Brain in Motion study
dc.typemaster thesis
thesis.degree.disciplineCardiovascular & Respiratory Sciences
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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