Synthesis of Polyionic Cyclodextrin Hosts and the Characterization of Their Inclusion Complexes with Steroids

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dc.contributor.advisorLing, Chang-Chun
dc.contributor.authorAchebe, Nnenna E
dc.contributor.committeememberMacCallum, Justin
dc.contributor.committeememberDerksen, Darren
dc.contributor.committeememberAnikovskiy, Max
dc.date2022-11
dc.date.accessioned2022-07-05T16:46:19Z
dc.date.available2022-07-05T16:46:19Z
dc.date.issued2022-06
dc.description.abstractThe work presented in this thesis is concerned with modified polyionic cyclodextrins and their structural functionality with regards to forming host-guest inclusion complexes. Cyclodextrins are well-known to encapsulate a variety of hydrophobic molecules: however, only a few studies have been conducted to understand the impact of extending the cavity of well-defined cyclodextrins using alkyl side-chains with like charges on their termini. In Chapter 1:, the history and background information about cyclodextrin inclusion complexes was provided, along with a discussion of the precedence in literature and the theory surrounding the study of these supramolecular systems. Subsequently, Chapter 2: presented an outline of the synthetic schemes, and the work that was done, along with characterizations towards the polyionic cyclodextrin hosts that were then used for the analysis. Finally, in Chapter 3:, inclusion complexes between the synthesized polyionic hosts and a selection of steroid guest molecules were studied. NMR studies and ITC were used to gain a better understanding that the role the extension of the cavity played, as well as the impact of charges on the host molecule on the interaction with neutral and charged guest molecules. The guest molecules of choice were primarily steroid molecules, which are known to form complexes with cyclodextrin. Through these studies, binding constants, along with the thermodynamic parameters were obtained.en_US
dc.identifier.citationAchebe, N. E. (2022). Synthesis of polyionic cyclodextrin hosts and the characterization of their inclusion complexes with steroids (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/39867
dc.identifier.urihttp://hdl.handle.net/1880/114797
dc.language.isoengen_US
dc.publisher.facultyScienceen_US
dc.publisher.institutionUniversity of Calgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.en_US
dc.subjectOrganic chemistryen_US
dc.subjectbioorganic chemistryen_US
dc.subjectsynthesisen_US
dc.subjectphysical chemistryen_US
dc.subjectcyclodextrinen_US
dc.subjectinclusion complexen_US
dc.subjectdrug deliveryen_US
dc.subjectsteroiden_US
dc.subjectNMRen_US
dc.subjectIsothermal Titration Calorimetry (ITC)en_US
dc.subject.classificationEducation--Sciencesen_US
dc.titleSynthesis of Polyionic Cyclodextrin Hosts and the Characterization of Their Inclusion Complexes with Steroidsen_US
dc.typemaster thesisen_US
thesis.degree.disciplineChemistryen_US
thesis.degree.grantorUniversity of Calgaryen_US
thesis.degree.nameMaster of Science (MSc)en_US
ucalgary.item.requestcopytrueen_US
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