The Effect of Plan Modulation on Dosimetric Effects due to Interplay in Hypofractionated Volumetric Modulated Arc Therapy Liver Radiotherapy Treatments

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atmire.migration.oldid4901
dc.contributor.advisorPierce, Greg
dc.contributor.authorHubley, Emily
dc.contributor.committeememberRoumeliotis, Michael
dc.contributor.committeememberSinha, Richie
dc.contributor.committeememberSmith, Wendy
dc.date.accessioned2016-09-19T18:46:07Z
dc.date.available2016-09-19T18:46:07Z
dc.date.issued2016
dc.date.submitted2016en
dc.description.abstractWhen tumours that move with respiration are treated using radiation therapy techniques with dynamic beam intensity modulation, including volumetric modulated arc therapy (VMAT), the interplay between tumour motion and multileaf collimator (MLC) leaf motions may cause differences between the planned and delivered dose distributions. These interplay effects may cause underdosage in the tumour, potentially reducing treatment efficacy. This uncertainty has led to hesitation in using VMAT to treat sites impacted by respiratory motion. These differences may be greater when more MLC leaf modulation is present. To investigate the magnitude of interplay effects in a digital phantom and ten patients, a program was written to simulate respiratory motion in hypofractionated VMAT liver treatment plans with varying amounts of MLC leaf modulation. It was found that highly modulated plans were more susceptible to interplay effects, but these effects were clinically negligible in magnitude due to the hotspot present in hypofractionated treatment plans.en_US
dc.identifier.citationHubley, E. (2016). The Effect of Plan Modulation on Dosimetric Effects due to Interplay in Hypofractionated Volumetric Modulated Arc Therapy Liver Radiotherapy Treatments (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/28089en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/28089
dc.identifier.urihttp://hdl.handle.net/11023/3310
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectPhysics--Radiation
dc.subject.classificationThe Interplay Effecten_US
dc.subject.classificationRadiation Therapyen_US
dc.subject.classificationLiver Canceren_US
dc.subject.classificationVolumetric Modulated Arc Therapyen_US
dc.subject.classificationStereotactic Body Radiotherapyen_US
dc.subject.classificationRadiation Oncology Physicsen_US
dc.subject.classificationMedical Physicsen_US
dc.subject.classificationRespiratory Motionen_US
dc.titleThe Effect of Plan Modulation on Dosimetric Effects due to Interplay in Hypofractionated Volumetric Modulated Arc Therapy Liver Radiotherapy Treatments
dc.typemaster thesis
thesis.degree.disciplinePhysics and Astronomy
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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