Exploring the Metabolic Networks of the Nematodes Caenorhabditis elegans and Ascaris suum for Potential Drug Targets
| atmire.migration.oldid | 2774 | |
| dc.contributor.advisor | Wasmuth, James | |
| dc.contributor.author | Li, Keyu | |
| dc.date.accessioned | 2014-12-03T22:31:15Z | |
| dc.date.available | 2015-02-23T08:00:31Z | |
| dc.date.issued | 2014-12-03 | |
| dc.date.submitted | 2014 | en |
| dc.description.abstract | Ascaris suum and Ascaris lumbricoides are widespread parasitic nematodes infecting pigs and humans respectively, causing infections of health and economic importance. Resistance to the available drug treatments is emerging. Thus, there is an urgent need to explore novel drug targets. The free-living nematode Caenorhabditis elegans is regarded as an ideal model for investigating nematode development and biochemistry. Here, we carefully reconstructed the metabolic networks for C. elegans and A. suum. The differential expression of enzymes across the two species’ life-cycle stages gave an insight into the development of the parasite. Chokepoint analysis was performed in both species, and its robustness test on the C. elegans network validated the method’s capacity to imperfect metabolic reconstruction. We identified 208 chokepoint enzymes in A. suum, and five of them were predicted as potential drug targets. | en_US |
| dc.identifier.citation | Li, K. (2014). Exploring the Metabolic Networks of the Nematodes Caenorhabditis elegans and Ascaris suum for Potential Drug Targets (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/26114 | en_US |
| dc.identifier.doi | http://dx.doi.org/10.11575/PRISM/26114 | |
| dc.identifier.uri | http://hdl.handle.net/11023/1947 | |
| dc.language.iso | eng | |
| dc.publisher.faculty | Graduate Studies | |
| dc.publisher.faculty | Veterinary Medicine | |
| dc.publisher.institution | University of Calgary | en |
| dc.publisher.place | Calgary | en |
| dc.rights | University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission. | |
| dc.subject | Bioinformatics | |
| dc.subject.classification | metabolic network | en_US |
| dc.subject.classification | chokepoint analysis | en_US |
| dc.subject.classification | ascaris suum | en_US |
| dc.subject.classification | caenorhabditis elegans | en_US |
| dc.title | Exploring the Metabolic Networks of the Nematodes Caenorhabditis elegans and Ascaris suum for Potential Drug Targets | |
| dc.type | master thesis | |
| thesis.degree.grantor | University of Calgary | |
| thesis.degree.name | Master of Science (MSc) | |
| ucalgary.item.requestcopy | true |