Residual Force Enhancement Following Eccentric Contractions: A New Mechanism Involving Titin
Date
2016-01
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Publisher
American Physiology Society
Abstract
Eccentric muscle properties are not well characterized by the current paradigm of the molecular mechanism of contraction: the cross-bridge theory. Findings of force contributions by passive structural elements a decade ago paved the way for a new theory. Here, we present experimental evidence and theoretical support for the idea that the structural protein titin contributes to active force production, thereby explaining many of the unresolved properties of eccentric muscle contraction.
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Citation
Herzog, W., Schappacher, G., DuVall, M., Leonard, T. R., & Herzog, J. A. (2016). Residual Force Enhancement Following Eccentric Contractions: A New Mechanism Involving Titin. Physiology, 31(4), 300–312. https://doi.org/10.1152/physiol.00049.2014