New ileostomy formation and subsequent community-onset acute and chronic kidney disease: A population-based cohort study

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atmire.migration.oldid5823
dc.contributor.advisorJames, Matthew
dc.contributor.advisorDixon, Elijah
dc.contributor.authorSmith, Stephen
dc.contributor.committeememberRonksley, Paul
dc.contributor.committeememberBuie, W. Donald
dc.date.accessioned2017-08-23T16:22:48Z
dc.date.available2017-08-23T16:22:48Z
dc.date.issued2017
dc.date.submitted2017en
dc.description.abstractIleostomy formation results in a loss of colonic absorptive capacity, which may cause volume depletion and kidney disease; however, associations with acute kidney injury (AKI) and chronic kidney disease (CKD) are uncertain. This thesis reports a population-based cohort study that characterizes the relationships between ileostomy formation and subsequent community-onset AKI and CKD. A total of 19,889 patients that underwent surgery in Alberta, Canada between May 2002 and January 2015 were included; 4136 patients that underwent ileostomy formation were compared to 15,753 patients that underwent bowel resection without ileostomy formation. After statistical adjustment using logistic regression, ileostomy formation was associated with subsequent community-onset AKI (OR=4.08; 95% CI=3.62-4.61) and CKD (OR=4.71; 95% CI=3.84-5.77). A series of risk prediction models of these outcomes after ileostomy formation were subsequently developed and evaluated. Clinicians should be vigilant for kidney disease following ileostomy formation and future studies should focus on developing preventative strategies.en_US
dc.identifier.citationSmith, S. (2017). New ileostomy formation and subsequent community-onset acute and chronic kidney disease: A population-based cohort study (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/27092en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/27092
dc.identifier.urihttp://hdl.handle.net/11023/4029
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectMedicine and Surgery
dc.subject.otherAcute Kidney Injury
dc.subject.otherChronic Kidney Disease
dc.subject.otherIleostomy
dc.titleNew ileostomy formation and subsequent community-onset acute and chronic kidney disease: A population-based cohort study
dc.typemaster thesis
thesis.degree.disciplineCommunity Health Sciences
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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