Investigating the neural basis of multiphasic respiratory rhythm generation in the American Bullfrog

Baghdadwala, Mufaddal Imran

Investigating the neural basis of multiphasic respiratory rhythm generation in the American Bullfrog

dc.contributor.advisor	Wilson, Richard J. A.
dc.contributor.author	Baghdadwala, Mufaddal Imran
dc.contributor.committeemember	Antle, Michael C.
dc.contributor.committeemember	Whelan, Patrick J.
dc.date	2019-06
dc.date.accessioned	2019-04-08T18:25:33Z
dc.date.available	2019-04-08T18:25:33Z
dc.date.issued	2019-04-05
dc.description.abstract	We breathe from the day we are born to the day we die; admittedly a cliché, but true nonetheless. Breathing is in fact so vital that it has historically been associated with a mythical life force; the very term ‘spirit’ is derived from the Latin word for a breath – ‘spiritus’ (Vanhove, 2008). This breathing ‘force’, as ancient medical practitioners serendipitously guessed, underscores nearly all of the physiological functions of the body. From something as (relatively) simple as oxygenating the blood to the control of something as elusive as one's mood and general health – all appears to be rooted in breathing. The centuries-old curiosity to decipher this rhythmic activity is, therefore, understandable. Thankfully, we have come a long way from describing breathing as a force. The mechanism of breathing has been thoroughly investigated, and over the last century of effort, we have discovered the neural underpinnings of the breath, but I suspect our work in deciphering breathing has just begun – the neural controller of breathing in vertebrates is still unresolved. My efforts, through this thesis, attempt to add to this growing body of knowledge. I utilized the central nervous system of the American Bullfrog (Rana catesbeiana) because it is arguably one of the champion organisms to study the neural control of breathing (Krogh's principle). In very general terms, I first confirm that the neural controller of breathing in bullfrogs is comprised of two independent respiratory oscillators (rhythm generating components) which couple over the course of metamorphosis. Second, I demonstrate that the bullfrog brain-stem hosts a third, previously undiscovered, respiratory oscillator. Finally, I show that the necessity of discrete respiratory oscillators can only be demonstrated under some conditions indicating that oscillators are labile and state-dependent entities.	en_US
dc.identifier.citation	Baghdadwala, M. I. (2019). Investigating the neural basis of multiphasic respiratory rhythm generation in the American Bullfrog (Doctoral thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.	en_US
dc.identifier.doi	http://dx.doi.org/10.11575/PRISM/36344
dc.identifier.uri	http://hdl.handle.net/1880/110146
dc.language.iso	eng	en_US
dc.publisher.faculty	Cumming School of Medicine	en_US
dc.publisher.institution	University of Calgary	en
dc.rights	University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.	en_US
dc.subject	rhythm generation	en_US
dc.subject	central pattern generators	en_US
dc.subject	oscillators	en_US
dc.subject	breathing	en_US
dc.subject	ventilation	en_US
dc.subject	neural control of breathing	en_US
dc.subject	brainstem	en_US
dc.subject	amphibians	en_US
dc.subject	rana catesbeiana	en_US
dc.subject.classification	Neuroscience	en_US
dc.subject.classification	Physiology	en_US
dc.subject.classification	Zoology	en_US
dc.title	Investigating the neural basis of multiphasic respiratory rhythm generation in the American Bullfrog	en_US
dc.type	doctoral thesis	en_US
thesis.degree.discipline	Medicine – Neuroscience	en_US
thesis.degree.grantor	University of Calgary	en_US
thesis.degree.name	Doctor of Philosophy (PhD)	en_US
ucalgary.item.requestcopy	true