The Development of a Self-Build Power Supply Unit to Assess the Challenges and Barriers Associated with Designing a Malaria Diagnostic Detection Device

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atmire.migration.oldid1602
dc.contributor.advisorvan Marle, Guido
dc.contributor.authorPrebeau-Menezes, Leif
dc.date.accessioned2013-10-10T18:21:02Z
dc.date.available2014-03-15T07:00:14Z
dc.date.issued2013-10-10
dc.date.submitted2013en
dc.description.abstractMalaria remains a serious public health problem across tropical and sub-tropical areas of Africa and around the globe. A potential solution lies in areas of biomedical research such as the development of a Malaria Diagnostic Detection Device (MDDD) and similar Point of Care (POC) devices. These diagnostic devices provide timely results leading to rapid clinical management decisions and patient care. Trials on some high technology POC devices have failed to deliver appropriate diagnostics in Africa due to the lack of availability of portable power utilities, specialized operational and maintenance training, and increasingly sophisticated supporting components, which were not available locally. Therefore, before major investments were made in developing the MDDD, a Self-Build Power Supply Unit (SBPSU) was constructed. It consisted of simple components that could be easily constructed, operated and maintained locally and economically in Ethiopia. The SBPSU replicates were tested and resulted in successfully running gel-electrophoresis units. The construction and replication of the SBPSU was also used to train research participants at the University of Gondar in Ethiopia. The outcome of this research provided an assessment of the requirements for developing the MDDD for use in Ethiopia. The lessons learned were incorporated into the design basis for the MDDD based on Loop mediated isothermal AMPlification (LAMP) assays for an accurate and rapid detection of malaria. It is expected that the implications of this work will foster future international biomedical research collaborations and provide insights for the next generation of POC infectious diseases detection devices.en_US
dc.identifier.citationPrebeau-Menezes, L. (2013). The Development of a Self-Build Power Supply Unit to Assess the Challenges and Barriers Associated with Designing a Malaria Diagnostic Detection Device (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/28058en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/28058
dc.identifier.urihttp://hdl.handle.net/11023/1146
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectEducation--Sciences
dc.subjectHuman Development
dc.subjectEngineering--Biomedical
dc.subject.classificationAfricaen_US
dc.subject.classificationBiomedical Engineeringen_US
dc.subject.classificationDevelopmenten_US
dc.subject.classificationAfrican Developmenten_US
dc.subject.classificationPower Supplyen_US
dc.subject.classificationMalariaen_US
dc.subject.classificationDetection Deviceen_US
dc.subject.classificationSocial Entrepreneurshipen_US
dc.subject.classificationEmpowermenten_US
dc.titleThe Development of a Self-Build Power Supply Unit to Assess the Challenges and Barriers Associated with Designing a Malaria Diagnostic Detection Device
dc.typemaster thesis
thesis.degree.disciplineBiomedical Engineering
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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